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» Authors » Friedhelm Schroeder

Friedhelm Schroeder

Explore the profile of Friedhelm Schroeder including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 118
Citations 2592
Followers 0
Related Specialties
Biochemistry
Physiology
Biophysics
Top 10 Co-Authors
Ann B Kier
Avery L McIntosh
Barbara P Atshaves
Gregory G Martin
Huan Huang
Danilo Landrock
Kerstin K Landrock
Stephen M Storey
Anca D Petrescu
Heather A Hostetler
Published In
Biochemistry
Lipids
J Lipid Res
J Biol Chem
Am J Physiol Gastrointest Liver Physiol
Affiliations
Soon will be listed here.
Recent Articles
1.
High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice
Martin G, Landrock D, McIntosh A, Milligan S, Landrock K, Kier A, et al.
Lipids . 2020 Apr; 55(4):309-327. PMID: 32314395
Ad libitum-fed diets high in fat and carbohydrate (especially fructose) induce weight gain, obesity, and nonalcoholic fatty liver disease (NAFLD) in humans and animal models. However, interpretation is complicated since...
2.
Sterol Carrier Protein-2/Sterol Carrier Protein-x/Fatty Acid Binding Protein-1 Ablation Impacts Response of Brain Endocannabinoid to High-Fat Diet
Martin G, Seeger D, McIntosh A, Milligan S, Chung S, Landrock D, et al.
Lipids . 2019 Sep; 54(10):583-601. PMID: 31487051
Brain endocannabinoids (EC) such as arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) primarily originate from serum arachidonic acid (ARA), whose level is regulated in part by a cytosolic ARA-binding protein, that is,...
3.
Effect of liver fatty acid binding protein (L-FABP) gene ablation on lipid metabolism in high glucose diet (HGD) pair-fed mice
McIntosh A, Atshaves B, Martin G, Landrock D, Milligan S, Landrock K, et al.
Biochim Biophys Acta Mol Cell Biol Lipids . 2019 Mar; 1864(7):985-1004. PMID: 30910689
Liver fatty acid binding protein (L-FABP) is the major fatty acid binding/"chaperone" protein in hepatic cytosol. Although fatty acids can be derived from the breakdown of dietary fat and glucose,...
4.
Endothelial nitric oxide synthase protein distribution and nitric oxide production in endothelial cells along the coronary vascular tree
Heaps C, Bray J, McIntosh A, Schroeder F
Microvasc Res . 2018 Nov; 122:34-40. PMID: 30439484
Objective: Freshly isolated endothelial cells from both conduit arteries and microvasculature were used to test the hypothesis that eNOS protein content and nitric oxide production in coronary endothelial cells increases...
5.
Structural and Functional Interaction of Δ-Tetrahydrocannabinol with Liver Fatty Acid Binding Protein (FABP1)
Huang H, McIntosh A, Martin G, Dangott L, Kier A, Schroeder F
Biochemistry . 2018 Sep; 57(41):6027-6042. PMID: 30232874
Although serum Δ-tetrahydrocannabinol (Δ-THC) undergoes rapid hepatic clearance and metabolism, almost nothing is known regarding the mechanism(s) whereby this highly lipophilic phytocannabinoid is transported for metabolism/excretion. A novel NBD-arachidonoylethanolamide (NBD-AEA)...
6.
Impact of Fabp1 Gene Ablation on Uptake and Degradation of Endocannabinoids in Mouse Hepatocytes
McIntosh A, Huang H, Landrock D, Martin G, Li S, Kier A, et al.
Lipids . 2018 Sep; 53(6):561-580. PMID: 30203570
Liver fatty-acid-binding protein (FABP1, L-FABP) is the major cytosolic binding/chaperone protein for both precursor arachidonic acid (ARA) and the endocannabinoid (EC) products N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). Although FABP1 regulates...
7.
Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat
Martin G, Seeger D, McIntosh A, Chung S, Milligan S, Landrock D, et al.
Arch Biochem Biophys . 2018 May; 650:93-102. PMID: 29763591
Dysregulation of the hepatic endocannabinoid (EC) system and high fat diet (HFD) are associated with non-alcoholic fatty liver disease. Liver cytosol contains high levels of two novel endocannabinoid binding proteins-liver...
8.
Human Liver Fatty Acid Binding Protein-1 T94A Variant, Nonalcohol Fatty Liver Disease, and Hepatic Endocannabinoid System
Martin G, Landrock D, Dangott L, McIntosh A, Kier A, Schroeder F
Lipids . 2018 Mar; 53(1):27-40. PMID: 29488637
Hepatic endocannabinoids (EC) and their major binding/"chaperone" protein (i.e., liver fatty acid binding protein-1 [FABP1]) are associated with development of nonalcoholic fatty liver (NAFLD) in animal models and humans. Since...
9.
Δ-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by gene ablation
McIntosh A, Martin G, Huang H, Landrock D, Kier A, Schroeder F
J Lipid Res . 2018 Feb; 59(4):646-657. PMID: 29414765
Phytocannabinoids, such as Δ-tetrahydrocannabinol (THC), bind and activate cannabinoid (CB) receptors, thereby "piggy-backing" on the same pathway's endogenous endocannabinoids (ECs). The recent discovery that liver fatty acid binding protein-1 (FABP1)...
10.
Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice
Milligan S, Martin G, Landrock D, McIntosh A, Mackie J, Schroeder F, et al.
Biochim Biophys Acta Mol Cell Biol Lipids . 2018 Jan; 1863(3):323-338. PMID: 29307784
Although singly ablating Fabp1 or Scp2/Scpx genes may exacerbate the impact of high fat diet (HFD) on whole body phenotype and non-alcoholic fatty liver disease (NAFLD), concomitant upregulation of the...