Fredrick S Leach
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Explore the profile of Fredrick S Leach including associated specialties, affiliations and a list of published articles.
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14
Citations
120
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Recent Articles
1.
Gardner J, Khurana H, Leach F, Ayala A, Zhai J, Ro J
Arch Pathol Lab Med
. 2010 Sep;
134(9):1271-5.
PMID: 20807045
We report a case of ectopic prostate tissue with an associated prostatic adenocarcinoma occurring in the dome of the urinary bladder. A 62-year-old man presented with a 4-month history of...
2.
Velasco A, Corvalan A, Wistuba I, Riquelme E, Chuaqui R, Majerson A, et al.
Int J Cancer
. 2007 Dec;
122(8):1774-7.
PMID: 18076065
We investigated mismatch repair (MMR) gene expression in testicular cancer as a molecular marker for clinical outcome (recurrence, response to chemotherapy and death) using protein expression and specific genetic alterations...
3.
Koh M, Ittmann M, Kadmon D, Thompson T, Leach F
Cancer Biol Ther
. 2005 Dec;
5(1):78-83.
PMID: 16357515
Targeted therapy of proteasome regulated gene expression has potential utility in cancer treatment since components of ubiquitin-mediated proteolysis are altered in human malignancy. Specific regulators of proteasome degradation such as...
4.
Prtilo A, Leach F, Markwalder R, Kappeler A, Burkhard F, Cecchini M, et al.
J Urol
. 2005 Oct;
174(5):1814-8.
PMID: 16217293
Purpose: Mismatch repair genes are responsible for the coordinated correction of misincorporated nucleotides formed during DNA replication. Mismatch repair expression is altered in a subset of prostate cancers (PCs) and...
5.
Prostate specific antigen as a clinical biomarker for prostate cancer: what's the take home message?
Leach F, Koh M, Chan Y, Bark S, Ray R, Morton R, et al.
Cancer Biol Ther
. 2005 Apr;
4(4):371-5.
PMID: 15846084
Prostate specific antigen (PSA) continues to be challenged as a legitimate clinical biomarker in early detection of prostate cancer due to lack of specificity for malignant transformation. Skepticism surrounding the...
6.
Velasco A, Riquelme E, Schultz M, Wistuba I, Villarroel L, Koh M, et al.
Cancer Biol Ther
. 2004 Oct;
3(11):1152-8.
PMID: 15492498
Germ cell tumor (GCT) is the most common genitourinary malignancy of men between the ages of 18 and 35 years. Therapy is ultimately successful in over 90% of patients, however...
7.
Velasco A, Riquelme E, Schultz M, Wistuba I, Villarroel L, Pizarro J, et al.
Cancer Biol Ther
. 2004 Oct;
3(10):977-82.
PMID: 15467433
Human mismatch repair (MMR) genes encode highly conserved interacting proteins that correct replication errors predisposing to hereditary gastrointestinal and genitourinary malignancies. A subset of sporadic genitourinary tumors also exhibits MMR...
8.
Leach F
Cancer Biol Ther
. 2004 Mar;
3(5):441-6.
PMID: 15004532
An inherited or familial predisposition to form kidney tumors represents less than 4% of all renal malignancies. However, hereditary renal cancer (HRC) syndromes offer important opportunities for gene discovery and...
9.
Kim I, Lee D, Lee D, Kim B, Kim H, Leach F, et al.
Clin Cancer Res
. 2003 Dec;
9(16 Pt 1):6046-51.
PMID: 14676131
Purpose: Bone morphogenetic proteins (BMPs) are members of a family of pleiotropic growth factors that play a critical role during renal development as well as maintaining kidney homeostasis. In the...
10.