Frederic Garzoni
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Explore the profile of Frederic Garzoni including associated specialties, affiliations and a list of published articles.
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20
Citations
678
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Recent Articles
1.
Buzas D, Sun H, Toelzer C, Yadav S, Borucu U, Gautam G, et al.
Structure
. 2024 Jan;
32(3):342-351.e6.
PMID: 38198950
Adenovirus-derived nanoparticles (ADDomer) comprise 60 copies of adenovirus penton base protein (PBP). ADDomer is thermostable, rendering the storage, transport, and deployment of ADDomer-based therapeutics independent of a cold chain. To...
2.
Buzas D, Bunzel A, Staufer O, Milodowski E, Edmunds G, Bufton J, et al.
Antib Ther
. 2023 Dec;
6(4):277-297.
PMID: 38075238
Background: Due to COVID-19, pandemic preparedness emerges as a key imperative, necessitating new approaches to accelerate development of reagents against infectious pathogens. Methods: Here, we developed an integrated approach combining...
3.
Toelzer C, Gupta K, Yadav S, Hodgson L, Kavanagh Williamson M, Buzas D, et al.
Sci Adv
. 2022 Nov;
8(47):eadc9179.
PMID: 36417532
As coronavirus disease 2019 (COVID-19) persists, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) emerge, accumulating spike (S) glycoprotein mutations. S receptor binding domain (RBD) comprises a...
4.
Gupta K, Toelzer C, Kavanagh Williamson M, Shoemark D, Oliveira A, Matthews D, et al.
Nat Commun
. 2022 Jan;
13(1):222.
PMID: 35017512
As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also...
5.
Sari-Ak D, Bufton J, Gupta K, Garzoni F, Fitzgerald D, Schaffitzel C, et al.
Curr Protoc
. 2021 Mar;
1(3):e55.
PMID: 33729713
Virus-like particles (VLPs) play a prominent role in vaccination as safe and highly versatile alternatives to attenuated or inactivated viruses or subunit vaccines. We present here two innovations, VLP-factory™ and...
6.
Toelzer C, Gupta K, Yadav S, Borucu U, Davidson A, Kavanagh Williamson M, et al.
Science
. 2020 Sep;
370(6517):725-730.
PMID: 32958580
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic development is unraveling the mechanisms that drive high infectivity,...
7.
Swale C, Da Costa B, Sedano L, Garzoni F, McCarthy A, Berger I, et al.
J Mol Biol
. 2020 Mar;
432(10):3353-3359.
PMID: 32222384
Here, we describe the crystal structures of two distinct isoforms of ligand-free human karyopherin RanBP5 and investigate its global propensity to interact with influenza A virus polymerase. Our results confirm...
8.
Vragniau C, Bufton J, Garzoni F, Stermann E, Rabi F, Terrat C, et al.
Sci Adv
. 2019 Oct;
5(9):eaaw2853.
PMID: 31620562
Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of...
9.
Sari-Ak D, Bahrami S, Laska M, Drncova P, Fitzgerald D, Schaffitzel C, et al.
Methods Mol Biol
. 2019 Jul;
2025:213-226.
PMID: 31267455
Baculovirus-based expression of proteins in insect cell cultures has emerged as a powerful technology to produce complex protein biologics for many applications ranging from multiprotein complex structural biology to manufacturing...
10.
Fallecker C, Caporossi A, Rechoum Y, Garzoni F, Larrat S, Francois O, et al.
Virol J
. 2017 Aug;
14(1):161.
PMID: 28830495
Background: The existing literature about HCV association with, and replication in mosquitoes is extremely poor. To fill this gap, we performed cellular investigations aimed at exploring (i) the capacity of...