Frans van Roy
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Explore the profile of Frans van Roy including associated specialties, affiliations and a list of published articles.
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109
Citations
4349
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Recent Articles
11.
Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al.
Front Immunol
. 2018 Jun;
9:1136.
PMID: 29881386
The CARD-coiled coil (CC)/Bcl10/MALT1-like paracaspase (CBM) signaling complexes composed of a CARD-CC family member (CARD-9, -10, -11, or -14), Bcl10, and the type 1 paracaspase MALT1 (PCASP1) play a pivotal...
12.
Gul I, Staal J, Hulpiau P, De Keuckelaere E, Kamm K, Deroo T, et al.
Genome Biol Evol
. 2018 Apr;
10(3):909-917.
PMID: 29608715
With the genomes available for many animal clades, including the early-branching metazoans, one can readily study the functional conservation of genes across a diversity of animal lineages. Ectopic expression of...
13.
Vanslembrouck B, Kremer A, Pavie B, van Roy F, Lippens S, van Hengel J
Histochem Cell Biol
. 2018 Mar;
149(5):479-490.
PMID: 29508067
The intercalated disc (ID) contains different kinds of intercellular junctions: gap junctions (GJs), desmosomes and areae compositae, essential for adhesion and communication between adjacent cardiomyocytes. The junctions can be identified...
14.
De Keuckelaere E, Hulpiau P, Saeys Y, Berx G, van Roy F
Cell Mol Life Sci
. 2018 Feb;
75(11):1929-1946.
PMID: 29397397
The hallmark of Nanos proteins is their typical (CCHC) zinc finger motif (zf-nanos). Animals have one to four nanos genes. For example, the fruit fly and demosponge have only one...
15.
Pieters T, Haenebalcke L, Bruneel K, Vandamme N, Hochepied T, van Hengel J, et al.
J Vis Exp
. 2017 May;
(122).
PMID: 28518103
Gene engineering in mouse embryos or embryonic stem cells (mESCs) allows for the study of the function of a given protein. Proteins are the workhorses of the cell and often...
16.
Gul I, Hulpiau P, Saeys Y, van Roy F
Exp Cell Res
. 2017 Mar;
358(1):3-9.
PMID: 28268172
Cadherin genes encode a superfamily of conserved transmembrane proteins that share an adhesive ectodomain composed of tandem cadherin repeats. More than 100 human cadherin superfamily members have been identified, which...
17.
van Hengel J, Van den Broeke C, Pieters T, Libbrecht L, Hofmann I, van Roy F
Eur J Cell Biol
. 2016 Oct;
95(12):574-584.
PMID: 27769530
p120 catenin (p120ctn) is required for the stability of classic cadherins at the cell surface and is thought to play a central role in modulating cell-cell adhesion. Cytoplasmic p120ctn promotes...
18.
Faura Tellez G, Willemse B, Brouwer U, Nijboer-Brinksma S, Vandepoele K, Noordhoek J, et al.
PLoS One
. 2016 Oct;
11(10):e0163967.
PMID: 27701444
Background: The asthma gene PCDH1 encodes Protocadherin-1, a putative adhesion molecule of unknown function expressed in the airway epithelium. Here, we characterize the localization, differential expression, homotypic adhesion specificity and...
19.
Pieters T, Goossens S, Haenebalcke L, Andries V, Stryjewska A, De Rycke R, et al.
PLoS Genet
. 2016 Aug;
12(8):e1006243.
PMID: 27556156
E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to downregulate their pluripotency program and are unable to initiate lineage commitment....
20.
Gul I, Hulpiau P, Saeys Y, van Roy F
Cell Mol Life Sci
. 2016 Aug;
74(3):525-541.
PMID: 27497926
The superfamily of armadillo repeat proteins is a fascinating archetype of modular-binding proteins involved in various fundamental cellular processes, including cell-cell adhesion, cytoskeletal organization, nuclear import, and molecular signaling. Despite...