Frank Roschangar
Overview
Explore the profile of Frank Roschangar including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
192
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Recent Articles
1.
Isidro-Llobet A, Kenworthy M, Mukherjee S, Kopach M, Wegner K, Gallou F, et al.
J Org Chem
. 2019 Mar;
84(8):4615-4628.
PMID: 30900880
In recent years, there has been a growing interest in therapeutic peptides within the pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 in clinical trials,...
2.
Sieber J, Buono F, Brusoe A, Desrosiers J, Haddad N, Lorenz J, et al.
J Org Chem
. 2019 Feb;
84(8):4926-4931.
PMID: 30715884
The application of a Buchwald's third generation palladacycle containing a dihydrobenzooxaphosphole-based ligand (e.g., BIDIME) was reported in the Suzuki cross-coupling reaction. Using flow technology, high yield and reproducible Suzuki cross-coupling...
3.
Nicolaou K, Roschangar F, Vourloumis D
Angew Chem Int Ed Engl
. 2018 May;
37(15):2014-2045.
PMID: 29711063
Only a few months after the disclosure of the absolute configuration of epothilones A (R=H, see picture on the right) and B (R=Me) the first total syntheses of these natural...
4.
Sieber J, Rodriguez S, Frutos R, Buono F, Zhang Y, Li N, et al.
J Org Chem
. 2018 Jan;
83(3):1448-1461.
PMID: 29323903
A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in five steps from the chiral auxiliary in 36% overall yield. Separtion and...
5.
Han Z, Wu H, Xu Y, Zhang Y, Qu B, Li Z, et al.
Org Lett
. 2017 Mar;
19(7):1796-1799.
PMID: 28351151
A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alcohol templates is described. These...
6.
Desrosiers J, Wei X, Gutierrez O, Savoie J, Qu B, Zeng X, et al.
Chem Sci
. 2017 Jan;
7(8):5581-5586.
PMID: 28111599
The direct arylation of pyridine substrates using non-precious catalysts is underdeveloped but highly desirable due to its efficiency to access important motifs while being extremely cost-effective. The first nickel-catalyzed C-3...
7.
Wei X, Qu B, Zeng X, Savoie J, Fandrick K, Desrosiers J, et al.
J Am Chem Soc
. 2016 Nov;
138(47):15473-15481.
PMID: 27794616
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total synthesis of 1 was...
8.
Marsini M, Reeves J, Desrosiers J, Herbage M, Savoie J, Li Z, et al.
Org Lett
. 2015 Nov;
17(22):5614-7.
PMID: 26558319
A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant α-quaternary amino esters...
9.
Fandrick D, Sanyal S, Kaloko J, Mulder J, Wang Y, Wu L, et al.
Org Lett
. 2015 Jun;
17(12):2964-7.
PMID: 26030838
A Michael equilibration model is presented to provide for site-selective pyrazole condensations between alkoxyacrylonitriles and hydrazines. Both pyrazole isomers were accessed with high selectivity by employment of kinetically or thermodynamically...
10.
Han Z, Zhang L, Xu Y, Sieber J, Marsini M, Li Z, et al.
Angew Chem Int Ed Engl
. 2015 Mar;
54(18):5474-7.
PMID: 25757595
The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a general, efficient, and highly...