Chris H Senanayake
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Explore the profile of Chris H Senanayake including associated specialties, affiliations and a list of published articles.
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158
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942
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Recent Articles
1.
Mangunuru H, Terrab L, Janganati V, Kalikinidi N, Tenneti S, Natarajan V, et al.
J Org Chem
. 2024 Apr;
89(9):6085-6099.
PMID: 38648720
Herein, we disclose a facile synthetic strategy to access an important class of drug molecules that contain chiral 1,2-amino alcohol functionality utilizing highly effective ruthenium-catalyzed asymmetric transfer hydrogenation of unprotected...
2.
Crull E, Buevich A, Martin G, Mahar R, Qu B, Senanayake C, et al.
Magn Reson Chem
. 2024 Mar;
62(8):573-582.
PMID: 38511664
β-lactams are a chemically diverse group of molecules with a wide range of biological activities. Having recently observed curious trends in J coupling values in studies on this structural class,...
3.
Robey J, Maity S, Aleshire S, Ghosh A, Yadaw A, Roy S, et al.
Org Process Res Dev
. 2023 Nov;
27(11):2146-2159.
PMID: 38025988
Bedaquiline (BDQ) is an important drug for treating multidrug-resistant tuberculosis (MDR-TB), a worldwide disease that causes more than 1.6 million deaths yearly. The current synthetic strategy adopted by the manufacturers...
4.
Shada A, Mangunuru H, Terrab L, Tenneti S, Kalikinidi N, Naini S, et al.
Org Lett
. 2023 Jul;
26(14):2751-2757.
PMID: 37486800
We report a new class of highly effective, benzooxaphosphole-based, water-soluble ligands in the application of Suzuki-Miyaura cross-coupling reactions for sterically hindered substrates in aqueous media. The catalytic activities of the...
5.
Desrosiers J, Xu Y, Kosnik S, Qu B, Lao K, Senanayake C, et al.
J Org Chem
. 2022 Aug;
87(16):11218-11221.
PMID: 35930810
ZPhos, as an effective ligand in the Cu-catalyzed asymmetric hydrogenation of ketones and aminoboration of alkenes, is prepared efficiently from the corresponding triflate of -chiral dihydrobenzoazaphosphole . However, the previous...
6.
Roy S, Yadaw A, Roy S, Sirasani G, Gangu A, Brown J, et al.
Org Process Res Dev
. 2022 Jan;
26(1):82-90.
PMID: 35095258
Pyrrolo[2,1-][1,2,4]triazine () is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound was produced through a newly developed synthetic methodology utilizing simple building blocks such...
7.
Kerner M, Kuttruff C, Chevliakov M, Buono F, Gao D, Krawiec M, et al.
Org Lett
. 2021 May;
23(11):4396-4399.
PMID: 33988373
The addition of carbamoyl anions to azirines affords synthetically useful 2-aziridinyl amide building blocks. The reaction scope was explored with respect to both formamide and azirine, and the addition was...
8.
Fandrick K, Patel N, Radomkit S, Chatterjee A, Braith S, Fandrick D, et al.
J Org Chem
. 2021 Mar;
86(6):4877-4882.
PMID: 33686865
A mild and nonreversible -butylation of alcohols and phenols can be achieved in high yields using the noncoordinating acid-base catalyst [bis(trifluoromethane)sulfonimide and 2,6-lutidine] with a -butylation reagent, -butyl 2,2,2-trichloroacetimidate. This...
9.
Liu M, Tang T, Apolinar O, Matsuura R, Busacca C, Qu B, et al.
J Am Chem Soc
. 2021 Mar;
143(10):3881-3888.
PMID: 33683868
Selective carbon-carbon (C-C) bond formation in chemical synthesis generally requires prefunctionalized building blocks. However, the requisite prefunctionalization steps undermine the overall efficiency of synthetic sequences that rely on such reactions,...
10.
Qu B, Samankumara L, Saha A, Schumer M, Han Z, Haddad N, et al.
Synlett
. 2021 Feb;
31(6):587-591.
PMID: 33542591
A series of new dihydrobenzooxophosphole-based Lewis Base organocatalysts were designed and synthesized. They are demonstrated effective in trichlorosilane-mediated stereoselective conjugate reductions of C=C bonds. DFT calculations reveal that the strong...