Hirsh Nanda
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Explore the profile of Hirsh Nanda including associated specialties, affiliations and a list of published articles.
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34
Citations
501
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Recent Articles
1.
Liu Q, Hong J, Zhang Y, Wang Q, Xia Q, Knierman M, et al.
Sci Rep
. 2024 Aug;
14(1):20239.
PMID: 39215123
Methods for the reliable and effective detection and identification of impurities are crucial to ensure the quality and safety of biopharmaceutical products. Technical limitations constrain the accurate identification of individual...
2.
Poltash M, Srzentic K, Beil E, Gorre E, Damoc E, Mahan A, et al.
J Am Soc Mass Spectrom
. 2023 Nov;
34(12):2654-2661.
PMID: 37922506
Multispecific antibody constructs are quickly becoming more common constructs in biopharmaceuticals to improve specificity and efficacy. While the advent of this technology has led to improved therapeutics, its development has...
3.
Gunawardena H, Jayatilake M, Brelsford J, Nanda H
Sci Rep
. 2023 Oct;
13(1):18602.
PMID: 37903854
Protein therapeutics are susceptible to clipping via enzymatic and nonenzymatic mechanisms that create neo-N-termini. Typically, neo-N-termini are identified by chemical derivatization of the N-terminal amine with (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP) followed...
4.
Waldenmaier H, Gorre E, Poltash M, Gunawardena H, Zhai X, Li J, et al.
J Am Soc Mass Spectrom
. 2023 May;
34(6):1073-1085.
PMID: 37186948
Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization of biotherapeutics. The system includes liquid and microplate handling robotics and utilities,...
5.
Boucher L, Prinslow E, Feldkamp M, Yi F, Nanjunda R, Wu S, et al.
MAbs
. 2023 Apr;
15(1):2195517.
PMID: 37074212
Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells. However, scFv domains...
6.
Thakkar S, Rodrigues D, Zhai B, Banton D, Somani S, Javidi A, et al.
J Pharm Sci
. 2022 Sep;
112(2):471-481.
PMID: 36130676
The rational design and selection of formulation composition to meet molecule-specific and product-specific needs are critical for biotherapeutics development to ensure physical and chemical stability. This work, based on three...
7.
Mouchahoir T, Schiel J, Rogers R, Heckert A, Place B, Ammerman A, et al.
J Am Soc Mass Spectrom
. 2022 Aug;
33(9):1659-1677.
PMID: 36018776
The multi-attribute method (MAM) was conceived as a single assay to potentially replace multiple single-attribute assays that have long been used in process development and quality control (QC) for protein...
8.
Nichols A, Kil Y, Mahan A, Zhai B, Hepler R, Nields K, et al.
J Am Soc Mass Spectrom
. 2021 Mar;
32(8):2013-2018.
PMID: 33765378
In the never-ending endeavor to produce stable and efficacious protein therapeutics, biopharmaceutical companies often employ numerous analytical techniques to characterize and quantify a drug candidate's stability. Mass spectrometry, due to...
9.
Mouchahoir T, Schiel J, Rogers R, Heckert A, Place B, Ammerman A, et al.
J Am Soc Mass Spectrom
. 2021 Mar;
32(4):913-928.
PMID: 33710905
The Multi-Attribute Method (MAM) Consortium was initially formed as a venue to harmonize best practices, share experiences, and generate innovative methodologies to facilitate widespread integration of the MAM platform, which...
10.
Hoogerheide D, Noskov S, Kuszak A, Buchanan S, Rostovtseva T, Nanda H
Acta Crystallogr D Struct Biol
. 2019 Jan;
74(Pt 12):1219-1232.
PMID: 30605136
Neutron reflectivity (NR) has emerged as a powerful technique to study the structure and behavior of membrane proteins at planar lipid interfaces. Integral membrane proteins (IMPs) remain a significant challenge...