Francois Vaillant
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Explore the profile of Francois Vaillant including associated specialties, affiliations and a list of published articles.
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56
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6397
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Recent Articles
1.
Dawson C, Milevskiy M, Capaldo B, Yip R, Song X, Vaillant F, et al.
Cell Rep
. 2024 Dec;
43(12):115073.
PMID: 39700014
Hormone-receptor-positive (HR) luminal cells largely mediate the response to estrogen and progesterone during mammary gland morphogenesis. However, there remains a lack of consensus on the precise nature of the precursor...
2.
Nightingale R, Reehorst C, Vukelic N, Papadopoulos N, Liao Y, Guleria S, et al.
Dev Cell
. 2024 May;
59(15):1988-2004.e11.
PMID: 38781975
The transcription factor EHF is highly expressed in the lactating mammary gland, but its role in mammary development and tumorigenesis is not fully understood. Utilizing a mouse model of Ehf...
3.
Joyce R, Pascual R, Heitink L, Capaldo B, Vaillant F, Christie M, et al.
Nat Cell Biol
. 2024 Jan;
26(1):138-152.
PMID: 38216737
Inheritance of a BRCA2 pathogenic variant conveys a substantial life-time risk of breast cancer. Identification of the cell(s)-of-origin of BRCA2-mutant breast cancer and targetable perturbations that contribute to transformation remains...
4.
Wang Z, Burigotto M, Ghetti S, Vaillant F, Tan T, Capaldo B, et al.
Cancer Discov
. 2023 Oct;
14(2):362-379.
PMID: 37877779
Significance: This study provides evidence that removal of mutant TP53, thereby deleting its reported GOF activities, does not impact the survival, proliferation, metastasis, or chemotherapy responses of cancer cells. Thus,...
5.
Sharma S, Chung C, Uryu S, Petrovic J, Cao J, Rickard A, et al.
Cell Chem Biol
. 2023 Aug;
30(10):1191-1210.e20.
PMID: 37557181
KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate histone H3K23 and exert an oncogenic role in several tumor types including breast cancer where KAT6A is frequently...
6.
Heitink L, Whittle J, Vaillant F, Capaldo B, Dekkers J, Dawson C, et al.
Mol Oncol
. 2022 Jan;
16(5):1119-1131.
PMID: 35000262
Breast cancer is a heterogeneous disease that comprises multiple histological and molecular subtypes. To gain insight into mutations that drive breast tumorigenesis, we describe a pipeline for the identification and...
7.
Yip R, Rimes J, Capaldo B, Vaillant F, Mouchemore K, Pal B, et al.
Nat Commun
. 2021 Nov;
12(1):6920.
PMID: 34836954
Bone marrow is a preferred metastatic site for multiple solid tumours and is associated with poor prognosis and significant morbidity. Accumulating evidence indicates that cancer cells colonise specialised niches within...
8.
Pal B, Chen Y, Milevskiy M, Vaillant F, Prokopuk L, Dawson C, et al.
Breast Cancer Res
. 2021 Jun;
23(1):69.
PMID: 34187545
Background: Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling. To further understand how cellular diversity changes during mammary ontogeny, we...
9.
Pal B, Chen Y, Vaillant F, Capaldo B, Joyce R, Song X, et al.
EMBO J
. 2021 May;
40(11):e107333.
PMID: 33950524
To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic BRCA1 tissue, the major breast cancer subtypes,...
10.
Grohmann C, Walker F, Devlin M, Luo M, Chueh A, Doherty J, et al.
Cell Death Dis
. 2021 Mar;
12(3):268.
PMID: 33712556
Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-effects, resistance...