Francois Sigaux
Overview
Explore the profile of Francois Sigaux including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
2718
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Recent Articles
1.
Sebert M, Gachet S, Leblanc T, Rousseau A, Bluteau O, Kim R, et al.
Cell Stem Cell
. 2023 Feb;
30(2):153-170.e9.
PMID: 36736290
Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid leukemia. Based on a longitudinal cohort of 335 patients, we performed clinical,...
2.
Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, et al.
Blood
. 2022 Mar;
139(24):3505-3518.
PMID: 35316324
Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, we performed RNA sequencing and whole-genome analyses in a large cohort of...
3.
Passet M, Boissel N, Sigaux F, Saillard C, Bargetzi M, Ba I, et al.
Blood
. 2018 Dec;
133(3):280-284.
PMID: 30510083
No abstract available.
4.
Gachet S, El-Chaar T, Avran D, Genesca E, Catez F, Quentin S, et al.
Cancer Discov
. 2018 Sep;
8(12):1614-1631.
PMID: 30266814
Deletion of chromosome 6q is a well-recognized abnormality found in poor-prognosis T-cell acute lymphoblastic leukemia (T-ALL). Using integrated genomic approaches, we identified two candidate haploinsufficient genes contiguous at 6q14, (encoding...
5.
Bruzzoni-Giovanelli H, Gonzalez J, Sigaux F, Villoutreix B, Cayuela J, Guilhot J, et al.
Oncotarget
. 2015 Oct;
6(34):36269-77.
PMID: 26474455
Little is known about inherited factors associated with the risk of developing chronic myelogenous leukemia (CML). We used a dedicated DNA chip containing 16 561 single nucleotide polymorphisms (SNPs) covering...
6.
Khaznadar Z, Boissel N, Agaugue S, Henry G, Cheok M, Vignon M, et al.
J Immunol
. 2015 Aug;
195(6):2580-90.
PMID: 26246143
Acute myeloid leukemia (AML) is a heterogeneous group of malignancies that may be sensitive to the NK cell antitumor response. However, NK cells are frequently defective in AML. In this...
7.
Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs A, et al.
Blood
. 2013 Dec;
123(7):1021-31.
PMID: 24335234
SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase and a nuclease that restricts HIV-1 in noncycling cells. Germ-line mutations in SAMHD1 have been described in patients with Aicardi-Goutières syndrome (AGS), a congenital...
8.
Delord M, Rousselot P, Cayuela J, Sigaux F, Guilhot J, Preudhomme C, et al.
Oncotarget
. 2013 Oct;
4(10):1582-91.
PMID: 24123600
Pharmacogenetic studies in chronic myelogenous leukemia (CML) typically use a candidate gene approach. In an alternative strategy, we analyzed the impact of single nucleotide polymorphisms (SNPs) in drug transporter genes...
9.
Verneuil L, Varna M, Ratajczak P, Leboeuf C, Plassa L, Elbouchtaoui M, et al.
J Clin Invest
. 2013 Aug;
123(9):3797-801.
PMID: 23979160
Tumor cells with donor genotype have been identified in human skin cancer after allogeneic transplantation; however, the donor contribution to the malignant epithelium has not been established. Kidney transplant recipients...
10.
Maharzi N, Parietti V, Nelson E, Denti S, Robledo-Sarmiento M, Setterblad N, et al.
J Immunol
. 2013 May;
190(12):6187-97.
PMID: 23690469
In this study, we identify transmembrane protein 131-like (TMEM131L) as a novel regulator of thymocyte proliferation and demonstrate that it corresponds to a not as yet reported inhibitor of Wnt...