Francois Nedelec
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Explore the profile of Francois Nedelec including associated specialties, affiliations and a list of published articles.
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Articles
55
Citations
2035
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Recent Articles
1.
Romeiro Motta M, Nedelec F, Saville H, Woelken E, Jacquerie C, Pastuglia M, et al.
Dev Cell
. 2024 Aug;
59(22):2947-2961.e9.
PMID: 39191252
To ensure an even segregation of chromosomes during somatic cell division, eukaryotes rely on mitotic spindles. Here, we measured prime characteristics of the Arabidopsis mitotic spindle and built a three-dimensional...
2.
Krattenmacher J, Lera-Ramirez M, Beber A, Herynek S, Grycova L, Liu X, et al.
Curr Biol
. 2024 Aug;
34(17):4071-4080.e6.
PMID: 39137787
Microtubules (MTs) are dynamically unstable polar biopolymers switching between periods of polymerization and depolymerization, with the switch from the polymerization to the depolymerization phase termed catastrophe and the reverse transition...
3.
Scrofani J, Ruhnow F, Chew W, Normanno D, Nedelec F, Surrey T, et al.
Mol Biol Cell
. 2023 Nov;
35(1):ar12.
PMID: 37991893
Chromosome segregation relies on the correct assembly of a bipolar spindle. Spindle pole self-organization requires dynein-dependent microtubule (MT) transport along other MTs. However, during M-phase RanGTP triggers MT nucleation and...
4.
Lugo C, Saikia E, Nedelec F
J Vis Exp
. 2023 Apr;
(194).
PMID: 37092845
Many cytoskeletal systems are now sufficiently well known to permit their precise quantitative modeling. Microtubule and actin filaments are well characterized, and the associated proteins are often known, as well...
5.
Ray S, Agarwal P, Nitzan A, Nedelec F, Zaidel-Bar R
Development
. 2023 Mar;
150(6).
PMID: 36897576
Actin dynamics play an important role in tissue morphogenesis, yet the control of actin filament growth takes place at the molecular level. A challenge in the field is to link...
6.
Chew W, Henkin G, Nedelec F, Surrey T
iScience
. 2023 Feb;
26(2):106063.
PMID: 36852161
Active filament networks can organize into various dynamic architectures driven by cross-linking motors. Densities and kinetic properties of motors and microtubules have been shown previously to determine active microtubule network...
7.
Henkin G, Chew W, Nedelec F, Surrey T
Proc Natl Acad Sci U S A
. 2022 Aug;
119(33):e2206398119.
PMID: 35960844
During cell division, cross-linking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear how motors with opposite directionality coordinate...
8.
Eliaz Y, Nedelec F, Morrison G, Levine H, Cheung M
Phys Rev E
. 2021 Jan;
102(6-1):062420.
PMID: 33466104
Quantifying the influence of microscopic details on the dynamics of development of the overall structure of a filamentous network is important in a number of biologically relevant contexts, but it...
9.
Alzahofi N, Welz T, Robinson C, Page E, Briggs D, Stainthorp A, et al.
Nat Commun
. 2020 Jul;
11(1):3495.
PMID: 32661310
Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we...
10.
Cortes D, Gordon M, Nedelec F, Maddox A
Biophys J
. 2020 May;
118(11):2703-2717.
PMID: 32365328
Molecular motors drive cytoskeletal rearrangements to change cell shape. Myosins are the motors that move, cross-link, and modify the actin cytoskeleton. The primary force generator in contractile actomyosin networks is...