Franco K C Au
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Explore the profile of Franco K C Au including associated specialties, affiliations and a list of published articles.
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8
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64
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Recent Articles
1.
Au F, Le K, Liao Z, Lin Z, Shen Y, Tong P, et al.
Mol Biol Cell
. 2025 Feb;
36(4):ar47.
PMID: 39969983
Growth arrest-specific 2-like 1 protein (GAS2L1) binds both actin and microtubules through its unique structural domains: a calponin-homology (CH) domain for actin binding and a GAS2-related (GAR) domain for microtubule...
2.
Trivedi P, Steele C, Au F, Alexandrov L, Cleveland D
Nature
. 2023 Jun;
618(7967):1049-1056.
PMID: 37316668
Chromothripsis, the shattering and imperfect reassembly of one (or a few) chromosome(s), is an ubiquitous mutational process generating localized and complex chromosomal rearrangements that drive genome evolution in cancer. Chromothripsis...
3.
Yang S, Au F, Li G, Lin J, Li X, Qi R
J Cell Biol
. 2023 May;
222(7).
PMID: 37213089
The γ-tubulin ring complex (γTuRC) is the principal nucleator of cellular microtubules, and the microtubule-nucleating activity of the complex is stimulated by binding to the γTuRC-mediated nucleation activator (γTuNA) motif....
4.
Au F, Le K, Qi R
Methods Mol Biol
. 2022 Dec;
2557:543-558.
PMID: 36512236
Golgi-derived microtubules constitute an asymmetrical microtubule network that drives polarized transport of vesicles to support cell polarization and directional migration. Golgi-based microtubule nucleation requires the γ-tubulin ring complex (γTuRC), the...
5.
Au F, Lui E, Qi R
STAR Protoc
. 2022 Mar;
3(1):101227.
PMID: 35284844
We present here a protocol to assay the centrosome separation events at late-G2 phase of the cell cycle by immunofluorescence microscopy. We describe the steps required for imaging and measurement...
6.
Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction
Au F, Hau B, Qi R
J Cell Biol
. 2020 Apr;
219(5).
PMID: 32289147
Centrosome disjunction occurs in late G2 to facilitate bipolar spindle formation and is mediated by the NIMA-related kinase Nek2. Here, we show that GAS2L1, a microtubule- and F-actin-binding protein required...
7.
Shen Y, Liu P, Jiang T, Hu Y, Au F, Qi R
Nat Commun
. 2017 Sep;
8(1):554.
PMID: 28916777
γ-Tubulin ring complexes (γTuRCs) initiate microtubule growth and mediate microtubule attachment at microtubule-organizing centers, such as centrosomes and the Golgi complex. However, the mechanisms that control γTuRC-mediated microtubule nucleation have...
8.
Fong K, Au F, Jia Y, Yang S, Zhou L, Qi R
J Biol Chem
. 2017 Mar;
292(18):7675-7687.
PMID: 28320860
Microtubules are polar cytoskeleton filaments that extend via growth at their plus ends. Microtubule plus-end-tracking proteins (+TIPs) accumulate at these growing plus ends to control microtubule dynamics and attachment. The...
9.
Au F, Jia Y, Jiang K, Grigoriev I, Hau B, Shen Y, et al.
Dev Cell
. 2016 Dec;
40(1):81-94.
PMID: 28017616
Mitotic spindle formation and chromosome segregation require timely separation of the two duplicated centrosomes, and this process is initiated in late G2 by centrosome disjunction. Here we report that GAS2L1,...