Franco Capozza
Overview
Explore the profile of Franco Capozza including associated specialties, affiliations and a list of published articles.
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25
Citations
1183
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Recent Articles
1.
Trimmer C, Sotgia F, Lisanti M, Capozza F
Am J Transl Res
. 2013 Feb;
5(1):80-91.
PMID: 23390568
Caveolin-1 (Cav1) is the main protein component of the membrane lipid rafts caveolae. Cav1 serves as a scaffolding protein that compartmentalizes a multitude of signaling molecules and sequesters them in...
2.
Trimmer C, Bonuccelli G, Katiyar S, Sotgia F, Pestell R, Lisanti M, et al.
Am J Pathol
. 2012 Dec;
182(3):992-1004.
PMID: 23267770
Caveolin-1 (Cav1) is a scaffolding protein that serves to regulate the activity of several signaling molecules. Its loss has been implicated in the pathogenesis of several types of cancer, but...
3.
Bonuccelli G, Castello-Cros R, Capozza F, Martinez-Outschoorn U, Lin Z, Tsirigos A, et al.
Cell Cycle
. 2012 Oct;
11(21):3972-82.
PMID: 23047602
Here, we identified the milk protein α-casein as a novel suppressor of tumor growth and metastasis. Briefly, Met-1 mammary tumor cells expressing α-casein showed a ~5-fold reduction in tumor growth...
4.
Capozza F, Trimmer C, Castello-Cros R, Katiyar S, Whitaker-Menezes D, Follenzi A, et al.
Cancer Res
. 2012 Mar;
72(9):2262-74.
PMID: 22396494
Both cell-autonomous and non-cell-autonomous factors contribute to tumor growth and metastasis of melanoma. The function of caveolin-1 (Cav1), a multifunctional scaffold protein known to modulate several biologic processes in both...
5.
Castello-Cros R, Bonuccelli G, Molchansky A, Capozza F, Witkiewicz A, Birbe R, et al.
Cell Cycle
. 2011 Jun;
10(12):2021-34.
PMID: 21646868
We have previously demonstrated that loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts is a strong and independent predictor of poor clinical outcome in human breast cancer patients. However, the...
6.
Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams T, et al.
Am J Pathol
. 2011 Jan;
178(1):402-12.
PMID: 21224077
Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However,...
7.
Trimmer C, Sotgia F, Whitaker-Menezes D, Balliet R, Eaton G, Martinez-Outschoorn U, et al.
Cancer Biol Ther
. 2010 Dec;
11(4):383-94.
PMID: 21150282
We have recently proposed a new model for understanding tumor metabolism, termed: "The Autophagic Tumor Stroma Model of Cancer Metabolism". In this new paradigm, catabolism (autophagy) in the tumor stroma...
8.
Martinez-Outschoorn U, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, et al.
Cell Cycle
. 2010 Sep;
9(17):3515-33.
PMID: 20855962
Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells induce oxidative stress in adjacent cancer-associated fibroblasts, resulting in the autophagic/lysosomal degradation of stromal caveolin-1 (Cav-1). However, the...
9.
Trimmer C, Whitaker-Menezes D, Bonuccelli G, Milliman J, Daumer K, Aplin A, et al.
Cancer Res
. 2010 Aug;
70(19):7489-99.
PMID: 20709760
Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events. Although evidence describing the function of CAV1...
10.
Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell R, Fatatis A, et al.
Cell Cycle
. 2010 May;
9(10):1960-71.
PMID: 20495363
We and others have previously identified a loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) as a powerful single independent predictor of breast cancer patient tumor recurrence, metastasis, tamoxifen-resistance,...