Gloria Bonuccelli
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Explore the profile of Gloria Bonuccelli including associated specialties, affiliations and a list of published articles.
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55
Citations
2612
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Recent Articles
1.
Bonuccelli G, Brooks D, Shepherd S, Sotgia F, Lisanti M
Aging (Albany NY)
. 2023 Nov;
15(21):11764-11781.
PMID: 37950722
Aging is a continuous degenerative process caused by a progressive decline of cell and tissue functions in an organism. It is induced by the accumulation of damage that affects normal...
2.
Bonuccelli G, Sotgia F, Lisanti M
Aging (Albany NY)
. 2022 Dec;
14(23):9466-9483.
PMID: 36455875
Here, we report the identification of key compounds that effectively inhibit the anchorage-independent growth and propagation of cancer stem cells (CSCs), as determined via screening using MCF7 cells, a human...
3.
Avnet S, Chano T, Massa A, Bonuccelli G, Lemma S, Falzetti L, et al.
Am J Cancer Res
. 2019 Jul;
9(6):1127-1144.
PMID: 31285947
Extracellular acidification is a very common cause of stress in tumor microenvironment and of Darwinian pressure. In acid areas of the tumor, most cancer cells are-albeit slowly proliferating-more resistant to...
4.
Sotgia F, Ozsvari B, Fiorillo M, De Francesco E, Bonuccelli G, Lisanti M
Cell Cycle
. 2018 Sep;
17(17):2091-2100.
PMID: 30257595
Here, we wish to propose a new systematic approach to cancer therapy, based on the targeting of mitochondrial metabolism, especially in cancer stem cells (CSCs). In the future, we envision...
5.
Bonuccelli G, Sotgia F, Lisanti M
Aging (Albany NY)
. 2018 Aug;
10(8):1867-1883.
PMID: 30153655
Matcha green tea (MGT) is a natural product that is currently used as a dietary supplement and may have significant anti-cancer properties. However, the molecular mechanism(s) underpinning its potential health...
6.
Peiris-Pages M, Bonuccelli G, Sotgia F, Lisanti M
Oncotarget
. 2018 Mar;
9(17):13254-13275.
PMID: 29568355
Mitochondria are dynamic organelles frequently undergoing fission and fusion events to maintain their integrity, bioenergetics and spatial distribution, which is fundamental to the processes of cell survival. Disruption in mitochondrial...
7.
Ozsvari B, Bonuccelli G, Sanchez-Alvarez R, Foster R, Sotgia F, Lisanti M
Aging (Albany NY)
. 2017 Dec;
9(12):2610-2628.
PMID: 29253841
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors. This screening platform was specifically designed to detect compounds that selectively deplete cellular ATP levels, but have little or...
8.
Ozsvari B, Fiorillo M, Bonuccelli G, Cappello A, Frattaruolo L, Sotgia F, et al.
Oncotarget
. 2017 Oct;
8(40):67457-67472.
PMID: 28978045
The "endo-symbiotic theory of mitochondrial evolution" states that mitochondrial organelles evolved from engulfed aerobic bacteria, after millions of years of symbiosis and adaptation. Here, we have exploited this premise to...
9.
De Francesco E, Bonuccelli G, Maggiolini M, Sotgia F, Lisanti M
Oncotarget
. 2017 Oct;
8(40):67269-67286.
PMID: 28978032
Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively...
10.
Bonuccelli G, De Francesco E, de Boer R, Tanowitz H, Lisanti M
Oncotarget
. 2017 Feb;
8(13):20667-20678.
PMID: 28223550
Here, we assembled a broad molecular "tool-kit" to interrogate the role of metabolic heterogeneity in the propagation of cancer stem-like cells (CSCs). First, we subjected MCF7 cells to "metabolic fractionation"...