Francisco Jaime Bezerra Mendonca-Junior
Overview
Explore the profile of Francisco Jaime Bezerra Mendonca-Junior including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
163
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Recent Articles
1.
Magalhaes D, Sidronio M, Nogueira N, Carvalho D, de Freitas M, Oliveira E, et al.
Microorganisms
. 2025 Feb;
13(2).
PMID: 40005637
Cardiotonic steroids modulate various aspects of the inflammatory response. The synthetic cardiotonic steroid γ-benzylidene digoxin 15 (BD-15), a digoxin derivative, has emerged as a promising candidate with potential immunomodulatory effects....
2.
Santos Aquino de Araujo R, Bernardo V, Tiburcio R, Bedor D, Campos M, Pontarolo R, et al.
Pharmaceuticals (Basel)
. 2025 Jan;
18(1).
PMID: 39861186
: Leishmaniasis is one of the 20 Neglected Tropical Diseases according to the WHO, affecting approximately 12 million people in four continents, generating serious public health problems. The lack of...
3.
Nunes J, Santos-Junior P, Gomes M, Ferreira L, Padilha E, Teixeira T, et al.
Eur J Med Chem
. 2024 Dec;
283():117109.
PMID: 39653622
Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T. brucei) urgently demand innovative drug development due to their impact on public health worldwide. Their cysteine proteases, Cruzain (CRZ) and the T....
4.
Barros de Menezes R, de Sousa N, Herrera-Acevedo C, Santos Aquino de Araujo R, Durand Trigueiro Lira N, Tavares J, et al.
ChemMedChem
. 2024 Oct;
20(4):e202400743.
PMID: 39476400
Leishmaniasis, caused by Leishmania parasites, presents a major global health challenge due to limitations of existing treatments, including toxicity, side effects, drug resistance, and high costs. This study utilized the...
5.
Leite F, Rodrigues L, Oliveira B, Duarte G, Leite Ferreira M, de Sousa N, et al.
Nat Prod Res
. 2024 Sep;
:1-12.
PMID: 39257335
Leishmaniasis is a group of neglected, vector-borne infectious diseases that affect millions of people around the world. The medications available for its treatment, especially in cases of visceral leishmaniasis, are...
6.
Santos-Junior P, Batista V, Nascimento I, Nunes I, Silva L, Costa C, et al.
Bioorg Med Chem
. 2024 Jun;
108:117774.
PMID: 38833750
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which remains a significant global health challenge. The emergence of multidrug-resistant (MDR) Mtb strains imposes the development of new...
7.
Mendonca-Junior F
Pharmaceuticals (Basel)
. 2024 Feb;
17(2).
PMID: 38399391
Protozoal diseases, such as leishmaniasis, malaria, African sleeping sickness, Chagas disease, amoebiasis, giardiasis, cryptococcosis, and toxoplasmosis (among others), affect and/or have the potential to infect more than one billion people...
8.
Maia M, Mendonca-Junior F, Rodrigues G, Silva A, Oliveira N, da Silva P, et al.
Molecules
. 2023 Aug;
28(16).
PMID: 37630263
Cancer is a multifactorial disease that continues to increase. Lignans are known to be important anticancer agents. However, due to the structural diversity of lignans, it is difficult to associate...
9.
Sousa J, de Sousa J, Rodrigues R, de Lima Nunes T, Machado Y, Araujo A, et al.
Int Immunopharmacol
. 2023 Aug;
123:110750.
PMID: 37536181
Leishmaniasis, presenting the highest number of cases worldwide is one of the most serious Neglected Tropical Diseases (NTDs). Clinical manifestations are intrinsically related to the host's immune response making immunomodulatory...
10.
Leite F, de Sousa N, Oliveira B, Duarte G, Leite Ferreira M, Scotti M, et al.
Molecules
. 2023 May;
28(10).
PMID: 37241750
Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties. Among the biological properties exerted by chalcones, their ability...