Francine Garrett-Bakelman
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Explore the profile of Francine Garrett-Bakelman including associated specialties, affiliations and a list of published articles.
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13
Citations
372
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Recent Articles
1.
Wu F, Du H, Overbey E, Kim J, Makhijani P, Martin N, et al.
Nat Commun
. 2024 Jun;
15(1):4795.
PMID: 38862487
Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated...
2.
Overbey E, Kim J, Tierney B, Park J, Houerbi N, Lucaci A, et al.
Nature
. 2024 Jun;
632(8027):1145-1154.
PMID: 38862028
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space. Yet...
3.
Mason C, Green J, Adamopoulos K, Afshin E, Baechle J, Basner M, et al.
Nature
. 2024 Jun;
632(8027):995-1008.
PMID: 38862027
The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space...
4.
Manichaikul A, Hu X, Logan J, Kwon Y, Lima J, Jacobs D, et al.
Res Sq
. 2023 Jul;
PMID: 37502922
Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding...
5.
Ganzel C, Sun Z, Baslan T, Zhang Y, Gonen M, Abdel-Wahab O, et al.
Leuk Res
. 2022 Nov;
123:106971.
PMID: 36332294
Measurable residual disease (MRD) assessment provides a potent indicator of the efficacy of anti-leukemic therapy. It is unknown, however, whether integrating MRD with molecular profiling better identifies patients at risk...
6.
Mencia-Trinchant N, MacKay M, Chin C, Afshinnekoo E, Foox J, Meydan C, et al.
Cell Rep
. 2021 Feb;
34(6):108740.
PMID: 33567281
No abstract available.
7.
Malkani S, Chin C, Cekanaviciute E, Mortreux M, Okinula H, Tarbier M, et al.
Cell Rep
. 2020 Nov;
33(10):108448.
PMID: 33242410
We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs...
8.
Gertz M, Chin C, Tomoiaga D, MacKay M, Chang C, Butler D, et al.
Cell Rep
. 2020 Nov;
33(10):108429.
PMID: 33242408
The National Aeronautics and Space Administration (NASA) Twins Study created an integrative molecular profile of an astronaut during NASA's first 1-year mission on the International Space Station (ISS) and included...
9.
Mencia-Trinchant N, MacKay M, Chin C, Afshinnekoo E, Foox J, Meydan C, et al.
Cell Rep
. 2020 Nov;
33(10):108458.
PMID: 33242405
Clonal hematopoiesis (CH) occurs when blood cells harboring an advantageous mutation propagate faster than others. These mutations confer a risk for hematological cancers and cardiovascular disease. Here, we analyze CH...
10.
Li S, Garrett-Bakelman F, Perl A, Luger S, Zhang C, To B, et al.
Genome Biol
. 2014 Sep;
15(9):472.
PMID: 25260792
We describe methclone, a novel method to identify epigenetic loci that harbor large changes in the clonality of their epialleles (epigenetic alleles). Methclone efficiently analyzes genome-wide DNA methylation sequencing data....