Francesco R Simonetti
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Explore the profile of Francesco R Simonetti including associated specialties, affiliations and a list of published articles.
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35
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1399
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Recent Articles
1.
Moskovljevic M, Dragoni F, Board N, Wu F, Lai J, Zhang H, et al.
Immunity
. 2024 Nov;
57(12):2928-2944.e6.
PMID: 39612916
Despite antiretroviral therapy (ART), HIV-1 persists in latently infected CD4 T cells, preventing a cure. Antigens drive the proliferation of infected cells, precluding latent reservoir decay. However, the relationship between...
2.
Reeves D, Rigau D, Romero A, Zhang H, Simonetti F, Varriale J, et al.
medRxiv
. 2024 Feb;
PMID: 38405967
The latent reservoir of HIV persists for decades in people living with HIV (PWH) on antiretroviral therapy (ART). To determine if persistence arises from the natural dynamics of memory CD4+...
3.
Board N, Yuan Z, Wu F, Moskovljevic M, Ravi M, Sengupta S, et al.
Nat Immunol
. 2024 Jan;
25(3):462-470.
PMID: 38278966
The persistence of CD4 T cells carrying latent human immunodeficiency virus-1 (HIV-1) proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune responses and clear infected...
4.
Kufera J, Armstrong C, Wu F, Singhal A, Zhang H, Lai J, et al.
J Exp Med
. 2024 Jan;
221(3).
PMID: 38270554
The latent reservoir for HIV-1 in resting CD4+ T cells persists despite antiretroviral therapy as a barrier to cure. The antigen-driven proliferation of infected cells is a major mechanism of...
5.
Sambaturu N, Fray E, Wu F, Zitzmann C, Simonetti F, Barouch D, et al.
bioRxiv
. 2023 Nov;
PMID: 37961482
HIV can persist in a latent form as integrated DNA (provirus) in resting CD4 T cells of infected individuals and as such is unaffected by antiretroviral therapy (ART). Despite being...
6.
Wu F, Simonetti F
Curr HIV/AIDS Rep
. 2023 Nov;
20(6):428-439.
PMID: 37955826
Purpose Of Review: In this review, we discuss what persistent viremia has taught us about the biology of the HIV-1 reservoir during antiretroviral therapy (ART). We will also discuss the...
7.
Dragoni F, Kwaa A, Traut C, Veenhuis R, Woldemeskel B, Camilo-Contreras A, et al.
J Clin Invest
. 2023 Sep;
133(21).
PMID: 37698927
BACKGROUNDHIV-1-infected CD4+ T cells contribute to latent reservoir persistence by proliferating while avoiding immune recognition. Integration features of intact proviruses in elite controllers (ECs) and people on long-term therapy suggest...
8.
McMyn N, Varriale J, Fray E, Zitzmann C, MacLeod H, Lai J, et al.
J Clin Invest
. 2023 Jul;
133(17).
PMID: 37463049
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t1/2 = 44 months)....
9.
Fray E, Wu F, Simonetti F, Zitzmann C, Sambaturu N, Molina-Paris C, et al.
Cell Host Microbe
. 2023 Feb;
31(3):356-372.e5.
PMID: 36809762
The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of antiretroviral therapy (ART). The...
10.
White J, Wu F, Yasin S, Moskovljevic M, Varriale J, Dragoni F, et al.
J Clin Invest
. 2023 Jan;
133(6).
PMID: 36602866
BackgroundAntiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV) originating from CD4+ T cell clones...