Francesca Sironi
Overview
Explore the profile of Francesca Sironi including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
891
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Recent Articles
1.
Noviello M, De Lorenzo R, Chimienti R, Maugeri N, De Lalla C, Siracusano G, et al.
Front Immunol
. 2024 Aug;
15:1381091.
PMID: 39136010
Introduction: SARS-CoV-2 pandemic still poses a significant burden on global health and economy, especially for symptoms persisting beyond the acute disease. COVID-19 manifests with various degrees of severity and the...
2.
Golia M, Frigerio R, Pucci S, Sironi F, Margotta C, Pasetto L, et al.
Exp Neurol
. 2024 Feb;
374:114716.
PMID: 38331161
SOD1 gene is associated with progressive motor neuron degeneration in the familiar forms of amyotrophic lateral sclerosis. Although studies on mutant human SOD1 transgenic rodent models have provided important insights...
3.
Sironi F, De Marchi F, Mazzini L, Bendotti C
Brain Res Bull
. 2023 Jan;
194:64-81.
PMID: 36690163
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the loss of motor neurons and neuromuscular impairment leading to complete paralysis, respiratory failure and premature death. The pathogenesis...
4.
Beghi E, Pupillo E, Bianchi E, Bonetto V, Luotti S, Pasetto L, et al.
Eur J Neurol
. 2022 Sep;
30(1):69-86.
PMID: 36148821
Background And Purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal...
5.
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD
Bauer C, Cohen R, Sironi F, Livesey M, Gillingwater T, Highley J, et al.
Acta Neuropathol
. 2022 Jul;
144(3):437-464.
PMID: 35876881
Dysfunction and degeneration of synapses is a common feature of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene is the main genetic...
6.
Trolese M, Scarpa C, Melfi V, Fabbrizio P, Sironi F, Rossi M, et al.
Mol Ther
. 2022 Apr;
30(8):2760-2784.
PMID: 35477657
Monocyte chemoattractant protein-1 (MCP1) is one of the most powerful pro-inflammatory chemokines. However, its signaling is pivotal in driving injured axon and muscle regeneration. We previously reported that MCP1 is...
7.
Apolloni S, Fabbrizio P, Amadio S, Napoli G, Freschi M, Sironi F, et al.
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34638992
Amyotrophic lateral sclerosis (ALS) is a disease with a resilient neuroinflammatory component caused by activated microglia and infiltrated immune cells. How to successfully balance neuroprotective versus neurotoxic actions through the...
8.
Dispinseri S, Secchi M, Pirillo M, Tolazzi M, Borghi M, Brigatti C, et al.
Nat Commun
. 2021 May;
12(1):2670.
PMID: 33976165
Understanding how antibody responses to SARS-CoV-2 evolve during infection may provide important insight into therapeutic approaches and vaccination for COVID-19. Here we profile the antibody responses of 162 COVID-19 symptomatic...
9.
Trolese M, Mariani A, Terao M, De Paola M, Fabbrizio P, Sironi F, et al.
EBioMedicine
. 2020 Nov;
62:103097.
PMID: 33161233
Background: CXCL13 is a B and T lymphocyte chemokine that mediates neuroinflammation through its receptor CXCR5. This chemokine is highly expressed by motoneurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) SOD1G93A...
10.
Malnati M, Biswas P, Ugolotti E, Di Marco E, Sironi F, Parolini F, et al.
HLA
. 2020 Jun;
96(3):312-322.
PMID: 32530084
Surface expression of human leukocyte antigen (HLA)-class I molecules is critical for modulating T/natural killer lymphocytes' effector functions. Among HLA molecules, HLA-C, the most recently evolved form of class I...