Florian Le Billan
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Explore the profile of Florian Le Billan including associated specialties, affiliations and a list of published articles.
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10
Citations
139
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Recent Articles
1.
Sahin C, Melanson J, Le Billan F, Magomedova L, Ferreira T, Oliveira A, et al.
Mol Metab
. 2024 May;
85:101958.
PMID: 38763495
Objective: The prevalence of metabolic diseases is increasing globally at an alarming rate; thus, it is essential that effective, accessible, low-cost therapeutics are developed. Peroxisome proliferator-activated receptors (PPARs) are transcription...
2.
Le Billan F, Umogbai G, Cummins C
Endocrinology
. 2023 May;
164(7).
PMID: 37226268
Steroid hormone signaling pathways are critical for organismal development and act through binding to nuclear receptors (NRs) driving transcriptional regulation. In this review, we summarize evidence for another-underrated-mechanism of action...
3.
Le Billan F, Perrot J, Carceller E, Travers S, Viengchareun S, Kolkhof P, et al.
FASEB J
. 2021 Jan;
35(2):e21314.
PMID: 33417258
Aldosterone, the main mineralocorticoid hormone in humans, plays a pivotal role in the control of water and salt reabsorption via activation of the mineralocorticoid receptor (MR). Alterations in MR signaling...
4.
Magomedova L, Tiefenbach J, Zilberman E, Le Billan F, Voisin V, Saikali M, et al.
Nucleic Acids Res
. 2019 Jan;
47(6):2856-2870.
PMID: 30698747
Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modulators of...
5.
Ayrout M, Le Billan F, Grange-Messent V, Mhaouty-Kodja S, Lombes M, Chauvin S
Psychoneuroendocrinology
. 2018 Sep;
99:47-56.
PMID: 30176377
Stress-induced reproductive dysfunction is frequently associated with increased glucocorticoid (GC) levels responsible for suppressed GnRH/LH secretion and impaired ovulation. Besides the major role of the hypothalamic kisspeptin system, other key...
6.
Le Billan F, Amazit L, Bleakley K, Xue Q, Pussard E, Lhadj C, et al.
FASEB J
. 2018 May;
32(10):5626-5639.
PMID: 29733691
Mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) are two closely related hormone-activated transcription factors that regulate major pathophysiologic functions. High homology between these receptors accounts for the crossbinding of their...
7.
Vitellius G, Fagart J, Delemer B, Amazit L, Ramos N, Bouligand J, et al.
Hum Mutat
. 2016 Apr;
37(8):794-803.
PMID: 27120390
Generalized glucocorticoid resistance is associated with glucocorticoid receptor (GR; NR3C1) mutations. Three novel heterozygous missense NR3C1 mutations (R477S, Y478C, and L672P) were identified in patients presenting with adrenal incidentalomas, glucocorticoid...
8.
Esber N, Le Billan F, Resche-Rigon M, Loosfelt H, Lombes M, Chabbert-Buffet N
PLoS One
. 2015 Oct;
10(10):e0140795.
PMID: 26474308
The progesterone receptor (PR) with its isoforms and ligands are involved in breast tumorigenesis and prognosis. We aimed at analyzing the respective contribution of PR isoforms, PRA and PRB, in...
9.
Amazit L, Le Billan F, Kolkhof P, Lamribet K, Viengchareun S, Fay M, et al.
J Biol Chem
. 2015 Jul;
290(36):21876-89.
PMID: 26203193
Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal...
10.
Le Billan F, Khan J, Lamribet K, Viengchareun S, Bouligand J, Fagart J, et al.
FASEB J
. 2015 Jun;
29(9):3977-89.
PMID: 26054365
Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulators and transcriptional machinery, leading to...