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» Authors » Florian D Vogel

Florian D Vogel

Explore the profile of Florian D Vogel including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 21
Followers 0
Related Specialties
Biology
Neurology
Pharmacology
Top 10 Co-Authors
Margot Ernst
Filip Koniuszewski
Thomas Seidel
Konstantina Bampali
Petra Scholze
Thierry Langer
Matias Wagner
Martin Krenn
Jure Fabjan
Matthaus Willeit
Published In
Br J Pharmacol
Cell Biol Toxicol
Epilepsia
Front Psychiatry
Front Mol Biosci
Affiliations
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Recent Articles
1.
De novo variants in GABRA4 are associated with a neurological phenotype including developmental delay, behavioral abnormalities and epilepsy
Sajan S, Gradisch R, Vogel F, Coffey A, Salyakina D, Soler D, et al.
Eur J Hum Genet . 2024 Apr; 32(8):912-919. PMID: 38565639
Nine out of 19 genes encoding GABA receptor subunits have been linked to monogenic syndromes characterized by seizures and developmental disorders. Previously, we reported the de novo variant p.(Thr300Ile) in...
2.
Navigating the complex landscape of benzodiazepine- and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond
Koniuszewski F, Vogel F, Dajic I, Seidel T, Kunze M, Willeit M, et al.
Front Psychiatry . 2023 Jul; 14:1188101. PMID: 37457785
Introduction: Medications which target benzodiazepine (BZD) binding sites of GABAA receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry labels as anxiolytics, hypnotics or antiepileptics. All benzodiazepines...
3.
GABA receptor-mediated seizure liabilities: a mixed-methods screening approach
Bampali K, Koniuszewski F, Vogel F, Fabjan J, Andronis C, Lekka E, et al.
Cell Biol Toxicol . 2023 Apr; 39(6):2793-2819. PMID: 37093397
GABA receptors, members of the pentameric ligand-gated ion channel superfamily, are widely expressed in the central nervous system and mediate a broad range of pharmaco-toxicological effects including bidirectional changes to...
4.
Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
Koniuszewski F, Vogel F, Bampali K, Fabjan J, Seidel T, Scholze P, et al.
Front Mol Biosci . 2022 May; 9:860246. PMID: 35615739
Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HTRs), zinc-activated channels (ZAC), γ-aminobutyric acid type A receptors (GABARs) and glycine receptors (GlyRs). They...
5.
A de novo missense variant in GABRA4 alters receptor function in an epileptic and neurodevelopmental phenotype
Vogel F, Krenn M, Westphal D, Graf E, Wagner M, Leiz S, et al.
Epilepsia . 2022 Feb; 63(4):e35-e41. PMID: 35152403
Variants in γ-aminobutyric acid A (GABA ) receptor genes cause different forms of epilepsy and neurodevelopmental disorders. To date, GABRA4, encoding the α4-subunit, has not been associated with a monogenic...
6.
Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABA receptors by two distinct mechanisms
Bampali K, Koniuszewski F, Silva L, Rehman S, Vogel F, Seidel T, et al.
Br J Pharmacol . 2022 Jan; 179(14):3675-3692. PMID: 35088415
Background And Purpose: Many psychotherapeutic drugs, including clozapine, display polypharmacology and act on GABA receptors. Patients with schizophrenia show alterations in function, structure and molecular composition of the hippocampus, and...