Petra Scholze
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Explore the profile of Petra Scholze including associated specialties, affiliations and a list of published articles.
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53
Citations
699
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Recent Articles
1.
Gorgulu I, Jagannath V, Pons S, Koniuszewski F, Groszer M, Maskos U, et al.
Eur J Neurosci
. 2024 Jul;
60(5):4893-4906.
PMID: 39073048
We investigated the impact of the human-specific gene CHRFAM7A on the function of α7 nicotinic acetylcholine receptors (α7 nAChRs) in two different types of neurons: human-induced pluripotent stem cell (hiPSC)-derived...
2.
Muller V, Ernst M, Baykuchkarova A, Koniuszewski F, Bampali K, Seidel T, et al.
Front Pharmacol
. 2024 Mar;
15:1368527.
PMID: 38549678
The plant-based alkaloid muscimol is a potent agonist of inhibitory GABA-neurotransmitter receptors. GABA receptors are a heterogeneous family of pentameric complexes, with 5 out of 19 subunits assembling around the...
3.
Sharmin D, Divovic B, Ping X, Cerne R, Smith J, Rezvanian S, et al.
ACS Chem Neurosci
. 2024 Jan;
15(3):517-526.
PMID: 38175916
KRM-II-81 (1) is an imidazodiazepine GABA receptor (GABAAR) potentiator with broad antiseizure efficacy and a low sedative burden. A brominated analogue, DS-II-73 (5), was synthesized and pharmacologically characterized as a...
4.
Huber A, Sarne V, Beribisky A, Ackerbauer D, Derdak S, Madritsch S, et al.
Stem Cells Dev
. 2024 Jan;
33(5-6):128-142.
PMID: 38164119
Rett Syndrome (RTT) is a severe neurodevelopmental disorder, afflicting 1 in 10,000 female births. It is caused by mutations in the X-linked (), which encodes for the global transcriptional regulator...
5.
Gajic Bojic M, Treven M, Pandey K, Tiruveedhula V, Santrac A, dukanovic D, et al.
Can J Physiol Pharmacol
. 2023 Nov;
102(3):206-217.
PMID: 37909404
Hypotensive influences of benzodiazepines and other GABA receptor ligands, recognized in clinical practice, seem to stem from the existence of "vascular" GABA receptors in peripheral blood vessels, besides any mechanisms...
6.
Arias H, De Deurwaerdere P, Scholze P, Sakamoto S, Hamachi I, Di Giovanni G, et al.
Eur J Pharmacol
. 2023 Jun;
953:175854.
PMID: 37331683
The sedative and anxiolytic-like activity of two coronaridine congeners, (+)-catharanthine and (-)-18-methoxycoronaridine (18-MC), was studied in male and female mice. The underlying molecular mechanism was subsequently determined by fluorescence imaging...
7.
Goisis R, Chiavegato A, Gomez-Gonzalo M, Marcon I, Requie L, Scholze P, et al.
Front Cell Neurosci
. 2022 Nov;
16:1066985.
PMID: 36339817
[This corrects the article DOI: 10.3389/fncel.2022.919493.].
8.
Simeone X, Ernst M, Seidel T, Heider J, Enz D, Monticelli S, et al.
Eur J Med Chem
. 2022 Oct;
244:114780.
PMID: 36279694
The family of GABA-A receptors contains nineteen mammalian subunits from which pentameric, GABA gated anion channels are assembled. The subunit encoded by the GABRA6 gene is highly expressed in the...
9.
Goisis R, Chiavegato A, Gomez-Gonzalo M, Marcon I, Requie L, Scholze P, et al.
Front Cell Neurosci
. 2022 Aug;
16:919493.
PMID: 35936501
Dravet Syndrome (DS) is a rare autosomic encephalopathy with epilepsy linked to Na1.1 channel mutations and defective GABAergic signaling. Effective therapies for this syndrome are lacking, urging a better comprehension...
10.
Koniuszewski F, Vogel F, Bampali K, Fabjan J, Seidel T, Scholze P, et al.
Front Mol Biosci
. 2022 May;
9:860246.
PMID: 35615739
Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HTRs), zinc-activated channels (ZAC), γ-aminobutyric acid type A receptors (GABARs) and glycine receptors (GlyRs). They...