Fiore Cattaruzza
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Explore the profile of Fiore Cattaruzza including associated specialties, affiliations and a list of published articles.
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20
Citations
818
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Recent Articles
1.
Cattaruzza F, Nazeer A, To M, Hammond M, Koski C, Liu L, et al.
Nat Cancer
. 2023 Mar;
4(4):485-501.
PMID: 36997747
To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth...
2.
Fischer M, Pete Yeung V, Cattaruzza F, Hussein R, Yen W, Murriel C, et al.
Sci Rep
. 2017 Nov;
7(1):15270.
PMID: 29127379
Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins that enhance Wnt signaling and RSPO2...
3.
Fischer M, Cancilla B, Pete Yeung V, Cattaruzza F, Chartier C, Murriel C, et al.
Sci Adv
. 2017 Jul;
3(6):e1700090.
PMID: 28691093
The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT pathway is frequently dysregulated in human cancers...
4.
Page M, Lourenco A, David T, LeBeau A, Cattaruzza F, Castro H, et al.
Nat Commun
. 2015 Oct;
6:8448.
PMID: 26423607
Functional imaging of proteolytic activity is an emerging strategy to quantify disease and response to therapy at the molecular level. We present a new peptide-based imaging probe technology that advances...
5.
Jensen D, Halls M, Murphy J, Canals M, Cattaruzza F, Poole D, et al.
J Biol Chem
. 2014 Jun;
289(29):20283-94.
PMID: 24898255
Although the intracellular trafficking of G protein-coupled receptors controls specific signaling events, it is unclear how the spatiotemporal control of signaling contributes to complex pathophysiological processes such as inflammation. By...
6.
Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk A, Cevikbas F, et al.
Am J Physiol Gastrointest Liver Physiol
. 2013 Apr;
304(11):G1002-12.
PMID: 23558009
Chronic pancreatitis (CP) is a devastating disease characterized by persistent and uncontrolled abdominal pain. Our lack of understanding is partially due to the lack of experimental models that mimic the...
7.
Alemi F, Kwon E, Poole D, Lieu T, Lyo V, Cattaruzza F, et al.
J Clin Invest
. 2013 Mar;
123(4):1513-30.
PMID: 23524965
Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which are elevated in the circulation and tissues during...
8.
Cattaruzza F, Poole D, Bunnett N
Biochem Soc Trans
. 2013 Jan;
41(1):137-43.
PMID: 23356273
GPCR (G-protein-coupled receptor) signalling at the plasma membrane is under tight control. In the case of neuropeptides such as SP (substance P), plasma membrane signalling is regulated by cell-surface endopeptidases...
9.
Alemi F, Poole D, Chiu J, Schoonjans K, Cattaruzza F, Grider J, et al.
Gastroenterology
. 2012 Oct;
144(1):145-54.
PMID: 23041323
Background & Aims: Abnormal delivery of bile acids (BAs) to the colon as a result of disease or therapy causes constipation or diarrhea by unknown mechanisms. The G protein-coupled BA...
10.
Lyo V, Cattaruzza F, Kim T, Walker A, Paulick M, Cox D, et al.
Am J Physiol Gastrointest Liver Physiol
. 2012 Aug;
303(8):G894-903.
PMID: 22899821
Cathepsins regulate premature trypsinogen activation within acinar cells, a key initial step in pancreatitis. The identity, origin, and causative roles of activated cathepsins in pancreatic inflammation and pain are not...