Fiona L Scott
Overview
Explore the profile of Fiona L Scott including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
23
Citations
1825
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Johnson Jr J, Focken T, Karimi Tari P, Dube C, Goodchild S, Andrez J, et al.
Br J Pharmacol
. 2024 Jun;
181(20):3993-4011.
PMID: 38922847
Background And Purpose: Inhibitors of voltage-gated sodium channels (Nas) are important anti-epileptic drugs, but the contribution of specific channel isoforms is unknown since available inhibitors are non-selective. We aimed to...
2.
Brar S, Vijan A, Scott F, Jimenez R, Zhang H, Grigoriadis D, et al.
Clin Pharmacol Drug Dev
. 2022 Dec;
12(4):447-456.
PMID: 36530055
Valbenazine and deutetrabenazine are vesicular monoamine transporter 2 (VMAT2) inhibitors approved for tardive dyskinesia. The clinical activity of valbenazine is primarily attributed to its only dihydrotetrabenazine (HTBZ) metabolite, [+]-α-HTBZ. Deutetrabenazine...
3.
Taylor Meadows K, Steinberg M, Clemons B, Stokes M, Opiteck G, Peach R, et al.
PLoS One
. 2018 Apr;
13(4):e0193236.
PMID: 29608575
Ozanimod (RPC1063) is a specific and potent small molecule modulator of the sphingosine 1-phosphate receptor 1 (S1PR1) and receptor 5 (S1PR5), which has shown therapeutic benefit in clinical trials of...
4.
Kitevska T, Roberts S, Pantaki-Eimany D, Boyd S, Scott F, Hawkins C
Biosci Rep
. 2016 Dec;
34(2).
PMID: 27919034
Caspase-2 is an evolutionarily conserved but enigmatic protease whose biological role remains poorly understood. To date, research into the functions of caspase-2 has been hampered by an absence of reagents...
5.
Hanson M, Roth C, Jo E, Griffith M, Scott F, Reinhart G, et al.
Science
. 2012 Feb;
335(6070):851-5.
PMID: 22344443
The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial development and integrity, heart rate, and vascular tone and maturation by activating G protein-coupled sphingosine 1-phosphate receptors. Here, we present the crystal...
6.
Nakamura T, Wang L, Wong C, Scott F, Eckelman B, Han X, et al.
Mol Cell
. 2010 Jul;
39(2):184-95.
PMID: 20670888
X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase apoptotic activity. XIAP also functions as an E3 ubiquitin ligase, targeting caspases for degradation. However, molecular pathways controlling XIAP...
7.
Sensintaffar J, Scott F, Peach R, Hager J
BMC Cancer
. 2010 Jan;
10:11.
PMID: 20067634
Background: The X-linked Inhibitor of Apoptosis (XIAP) has attracted much attention as a cancer drug target. It is the only member of the IAP family that can directly inhibit caspase...
8.
Walters J, Pop C, Scott F, Drag M, Swartz P, Mattos C, et al.
Biochem J
. 2009 Oct;
424(3):335-45.
PMID: 19788411
The caspase-3 zymogen has essentially zero activity until it is cleaved by initiator caspases during apoptosis. However, a mutation of V266E in the dimer interface activates the protease in the...
9.
Scott F, Stec B, Pop C, Dobaczewska M, Lee J, Monosov E, et al.
Nature
. 2009 Jan;
457(7232):1019-22.
PMID: 19118384
The death inducing signalling complex (DISC) formed by Fas receptor, FADD (Fas-associated death domain protein) and caspase 8 is a pivotal trigger of apoptosis. The Fas-FADD DISC represents a receptor...
10.
ORiordan M, Bauler L, Scott F, Duckett C
Dev Cell
. 2008 Oct;
15(4):497-508.
PMID: 18854135
The past decade and a half has witnessed the discovery of a large, evolutionarily conserved family of cellular genes bearing homology to the prototype baculovirus Inhibitor of Apoptosis (IAP). The...