Felix Machin
Overview
Explore the profile of Felix Machin including associated specialties, affiliations and a list of published articles.
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Articles
58
Citations
903
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Recent Articles
1.
Anaissi-Afonso L, Santana-Sosa S, Lorenzo-Castrillejo I, McNaughton-Smith G, Machin F
Heliyon
. 2025 Jan;
10(24):e41105.
PMID: 39759308
The naphthoquinone moiety is commonly found in numerous natural cytotoxic compounds with diverse and pleiotropic modes of action (MOAs). The moiety can exist as a standalone pharmacophore or combined with...
2.
Alvarez-Tosco K, Gonzalez-Fernandez R, Gonzalez-Nicolas M, Martin-Ramirez R, Morales M, Gutierrez R, et al.
BMC Neurosci
. 2024 Sep;
25(1):44.
PMID: 39278931
Background: Peripheral neuropathy (PN) constitutes a dose-limiting side effect of oxaliplatin chemotherapy that often compromises the efficacy of antineoplastic treatments. Sensory neurons damage in dorsal root ganglia (DRG) are the...
3.
Reyes C, Ardiles A, Anaissi-Afonso L, Gonzalez-Bakker A, Padron J, Jimenez I, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273417
To explore new compounds with antitumour activity, fifteen phenolic -tripterpenes isolated from Celastraceae species, , and , have been studied. Their chemical structures were elucidated through spectroscopic and spectrometric techniques,...
4.
Medina-Suarez S, Ayra-Plasencia J, Perez-Martinez L, Butter F, Machin F
iScience
. 2024 Jul;
27(7):110250.
PMID: 39021806
Precise double-strand break (DSB) repair is a paramount for genome stability. Homologous recombination (HR) repairs DSBs when cyclin-dependent kinase (CDK) activity is high, which correlates with the availability of the...
5.
Medina-Suarez S, Machin F
MicroPubl Biol
. 2024 Jan;
2024.
PMID: 38287928
CRISPR/Cas9 gene editing technology has revolutionized genetic engineering. However, the nuclear dynamics of Cas9 in eukaryotic cells, particularly in the model organism , remains poorly understood. Here, we constructed yeast...
6.
Morais-Armas S, Medina-Suarez S, Machin F
MicroPubl Biol
. 2023 Oct;
2023.
PMID: 37799204
The COVID-19 pandemic caused by SARS-CoV-2 has underscored the need for rapid and accurate diagnostic methods. Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) has emerged as a promising molecular tool in...
7.
Bruna-Haupt E, Perretti M, Garro H, Carrillo R, Machin F, Lorenzo-Castrillejo I, et al.
ACS Omega
. 2023 Jul;
8(29):26479-26496.
PMID: 37521653
A library of structurally related coumarins was generated through synthesis reactions and chemical modification reactions to obtain derivatives with antiproliferative activity both and . Out of a total of 35...
8.
Santana-Sosa S, Matos-Perdomo E, Ayra-Plasencia J, Machin F
Int J Mol Sci
. 2023 Jun;
24(12).
PMID: 37372977
The morphology of the nucleus is roughly spherical in most eukaryotic cells. However, this organelle shape needs to change as the cell travels through narrow intercellular spaces during cell migration...
9.
Prescott T, Anaissi-Afonso L, Fox K, Maxwell A, Panaretou B, Machin F
FEBS Lett
. 2022 Sep;
596(23):3087-3102.
PMID: 36053795
Elucidating the mechanism of action of an antifungal or cytotoxic compound is a time-consuming process. Yeast chemogenomic profiling provides a compelling solution to the problem but is experimentally complex. Here,...
10.
Matos-Perdomo E, Santana-Sosa S, Ayra-Plasencia J, Medina-Suarez S, Machin F
Life Sci Alliance
. 2022 Aug;
5(10).
PMID: 35961781
The ribosomal DNA (rDNA) array of has served as a model to address chromosome organization. In cells arrested before anaphase (mid-M), the rDNA acquires a highly structured chromosomal organization referred...