Felix H Shek
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Explore the profile of Felix H Shek including associated specialties, affiliations and a list of published articles.
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9
Citations
298
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Recent Articles
1.
Shek F, Luo R, Lam B, Sung W, Lam T, Luk J, et al.
Cell Oncol (Dordr)
. 2017 Jun;
40(5):443-456.
PMID: 28631187
Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. Previously, we reported that cadherin-17 (CDH17) and its related CDH17/β-catenin axis may be responsible for inducing HCC...
2.
Yeung B, Shek F, Lee N, Wong C
PLoS One
. 2015 Oct;
10(10):e0139977.
PMID: 26469082
Growing evidence has revealed high expression levels of stanniocalcin-1 (STC1) in different types of human cancers. Numerous experimental studies using cancer cell lines demonstrated the involvement of STC1 in inflammatory...
3.
Tsang F, Au V, Lu W, Shek F, Liu A, Luk J, et al.
Dig Dis Sci
. 2014 May;
59(10):2477-87.
PMID: 24811246
Background: MicroRNAs (miRNAs) belong to a group of small non-coding RNA with differential expression in tumors, including hepatocellular carcinoma (HCC). Aim: This study investigates the involvement of miR-125b in HCC....
4.
Liu A, Xu Z, Shek F, Wong K, Lee N, Poon R, et al.
PLoS One
. 2014 Jan;
9(1):e86872.
PMID: 24466275
In contrast to normal differentiated cells that depend on mitochondrial oxidative phosphorylation for energy production, cancer cells have evolved to utilize aerobic glycolysis (Warburg's effect), with benefit of providing intermediates...
5.
Wang Y, Shek F, Wong K, Liu L, Zhang X, Yuan Y, et al.
PLoS One
. 2013 Sep;
8(9):e72386.
PMID: 24039755
Cadherin-17 (CDH17) is an oncofetal molecule associated with poor prognostic outcomes of hepatocellular carcinoma (HCC), for which the treatment options are very limited. The present study investigates the therapeutic potential...
6.
Shek F, Fatima S, Lee N
Int J Hepatol
. 2012 Oct;
2012:760928.
PMID: 23029619
Hepatocellular carcinoma (HCC) is a primary liver malignancy and accounts for most of the total liver cancer cases. Lack of treatment options and late diagnosis contribute to high mortality rate...
7.
Luk J, Burchard J, Zhang C, Liu A, Wong K, Shek F, et al.
J Biol Chem
. 2011 Jul;
286(35):30706-30713.
PMID: 21737452
Hepatocellular carcinoma (HCC) is a heterogeneous and highly aggressive malignancy, for which there are no effective cures. Identification of a malignant stemlike subtype of HCC may offer patients with a...
8.
Lee N, Poon R, Shek F, Ng I, Luk J
Biochim Biophys Acta
. 2010 Jun;
1806(2):138-45.
PMID: 20580775
Cadherin is an important cell adhesion molecule that plays paramount roles in organ development and the maintenance of tissue integrity. Dysregulation of cadherin expression is often associated with disease pathology...
9.
Lee N, Tsang F, Shek F, Mao M, Dai H, Zhang C, et al.
Int J Cancer
. 2009 Dec;
127(4):968-76.
PMID: 19998337
Using comparative proteomic and genomic approaches, the authors identified eukaryotic translation initiation factor 5A (eIF5A) as an oncofetal molecule highly abundant in mouse embryonic livers and human hepatocellular carcinoma (HCC)...