John M Luk
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Explore the profile of John M Luk including associated specialties, affiliations and a list of published articles.
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126
Citations
5585
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Recent Articles
1.
Pei X, Wong H, Ng S, Leung W, Wong Y, Tsang H, et al.
Expert Rev Mol Diagn
. 2023 Feb;
23(2):171-179.
PMID: 36744385
Background: Colorectal cancer (CRC) is the second leading cause of cancer deaths in Hong Kong. We tested the hypothesis that circulating tumor cell (CTC) analysis by ARB101 antibody could be...
2.
Zheng B, Shen S, Wong K, Gong Z, Sun W, Ni X, et al.
J Surg Oncol
. 2021 Feb;
123(5):1253-1262.
PMID: 33524213
Background And Objectives: In this retrospective study, we examined the CA17 tissue expression and analyzed its clinical significance in cholangiocarcinoma (CCA). Materials And Methods: Immunohistochemistry was performed to assess CA17...
3.
Lum Y, Luk J, Staunton D, K P Ng D, Fong W
Mol Pharm
. 2020 Sep;
17(10):3941-3951.
PMID: 32931292
In cancer photodynamic therapy (PDT), a photosensitizer taken up by cancer cells can generate reactive oxygen species upon near-infrared light activation to induce cancer cell death. To increase PDT potency...
4.
McMahon M, Contreras A, Holm M, Uechi T, Forester C, Pang X, et al.
Elife
. 2019 Sep;
8.
PMID: 31478838
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered...
5.
Liu A, Wang W, Luk J
Hepat Oncol
. 2018 Sep;
1(3):323-329.
PMID: 30190966
Hepatocellular carcinoma (HCC) remains one of the most common malignancies worldwide, ranking as the third leading cause of cancer-related death. With recent advances in understanding HCC biology, progress has been...
6.
Shek F, Luo R, Lam B, Sung W, Lam T, Luk J, et al.
Cell Oncol (Dordr)
. 2017 Jun;
40(5):443-456.
PMID: 28631187
Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. Previously, we reported that cadherin-17 (CDH17) and its related CDH17/β-catenin axis may be responsible for inducing HCC...
7.
Wong K, Liu A, Hong W, Xu Z, Luk J
Oncotarget
. 2016 Oct;
7(47):77683-77695.
PMID: 27765911
The Hippo pathway regulates the down-stream target Yes-associated protein (YAP) to maintain organ homeostasis, which is commonly inactivated in many types of cancers. However, how cell adhesion dysregulates the Hippo...
8.
Lu W, Saxena N, Luk J, Kaul S, Wadhwa R
Cell Stress Chaperones
. 2015 Apr;
20(4):715-9.
PMID: 25905813
Mortalin is a stress chaperone belonging to the Hsp70 family of proteins. Frequently enriched in cancers, it is a multifunctional protein and regulates cell proliferation, apoptosis, mitochondrial functions, and the...
9.
Xu Z, Chen Y, Gu D, Lee N, Sun S, Gong W, et al.
Am J Transl Res
. 2015 Apr;
7(2):401-10.
PMID: 25901207
Adjuvant chemotherapy is a standard therapy for gastric cancer patients, however, treatment response is quite heterogeneous. Molecular biomarkers will be highly valuable to guide the therapy and predict the response...
10.
Kim J, Sohn B, Lee H, Kim S, Yoo J, Park Y, et al.
PLoS Med
. 2014 Dec;
11(12):e1001770.
PMID: 25536056
Background: Typically observed at 2 y after surgical resection, late recurrence is a major challenge in the management of hepatocellular carcinoma (HCC). We aimed to develop a genomic predictor that...