Felix G M Ernst
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Explore the profile of Felix G M Ernst including associated specialties, affiliations and a list of published articles.
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12
Citations
452
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Recent Articles
1.
Naarmann-de Vries I, Zorbas C, Lemsara A, Piechotta M, Ernst F, Wacheul L, et al.
RNA Biol
. 2023 Aug;
20(1):652-665.
PMID: 37635368
Ribosomal RNAs are decorated by numerous post-transcriptional modifications whose exact roles in ribosome biogenesis, function, and human pathophysiology remain largely unknown. Here, we report a targeted direct rRNA sequencing approach...
2.
Finet O, Yague-Sanz C, Kruger L, Tran P, Migeot V, Louski M, et al.
Mol Cell
. 2021 Nov;
82(2):404-419.e9.
PMID: 34798057
The epitranscriptome has emerged as a new fundamental layer of control of gene expression. Nevertheless, the determination of the transcriptome-wide occupancy and function of RNA modifications remains challenging. Here we...
3.
Duchemin A, OGrady T, Hanache S, Mereau A, Thiry M, Wacheul L, et al.
Nat Commun
. 2021 Nov;
12(1):6648.
PMID: 34789764
The U6 snRNA, the core catalytic component of the spliceosome, is extensively modified post-transcriptionally, with 2'-O-methylation being most common. However, how U6 2'-O-methylation is regulated remains largely unknown. Here we...
4.
de Wijn R, Rollet K, Ernst F, Wellner K, Betat H, Morl M, et al.
Comput Struct Biotechnol J
. 2021 Nov;
19:5845-5855.
PMID: 34765099
CCA-adding enzymes are highly specific RNA polymerases that add and maintain the sequence C-C-A at tRNA 3'-ends. Recently, we could reveal that cold adaptation of such a polymerase is not...
5.
Bizarro J, Deryusheva S, Wacheul L, Gupta V, Ernst F, Lafontaine D, et al.
Genes Dev
. 2021 Jul;
35(15-16):1123-1141.
PMID: 34301768
Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB)-specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA modification...
6.
Bizarro J, Deryusheva S, Wacheul L, Gupta V, Ernst F, Lafontaine D, et al.
bioRxiv
. 2021 May;
PMID: 33948588
Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB) specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA...
7.
Huang R, Soneson C, Ernst F, Rue-Albrecht K, Yu G, Hicks S, et al.
F1000Res
. 2021 Mar;
9:1246.
PMID: 33274053
Data organized into hierarchical structures (e.g., phylogenies or cell types) arises in several biological fields. It is therefore of interest to have data containers that store the hierarchical structure together...
8.
Tran N, Ernst F, Hawley B, Zorbas C, Ulryck N, Hackert P, et al.
Nucleic Acids Res
. 2019 Jul;
47(15):7719-7733.
PMID: 31328227
N6-methyladenosine (m6A) has recently been found abundantly on messenger RNA and shown to regulate most steps of mRNA metabolism. Several important m6A methyltransferases have been described functionally and structurally, but...
9.
de Wijn R, Hennig O, Ernst F, Lorber B, Betat H, Morl M, et al.
Acta Crystallogr F Struct Biol Commun
. 2018 Nov;
74(Pt 11):747-753.
PMID: 30387781
The determination of conditions for the reproducible growth of well diffracting crystals is a critical step in every biocrystallographic study. On the occasion of a new structural biology project, several...
10.
Marchand V, Ayadi L, Ernst F, Hertler J, Bourguignon-Igel V, Galvanin A, et al.
Angew Chem Int Ed Engl
. 2018 Oct;
57(51):16785-16790.
PMID: 30370969
RNA modifications play essential roles in gene expression regulation. Only seven out of >150 known RNA modifications are detectable transcriptome-wide by deep sequencing. Here we describe a new principle of...