Felicity N E Gavins
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Explore the profile of Felicity N E Gavins including associated specialties, affiliations and a list of published articles.
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65
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1521
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Recent Articles
11.
Iffah R, Gavins F
Br J Pharmacol
. 2021 Jun;
179(10):2100-2107.
PMID: 34128218
Since the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a disease that has become one of the world's greatest global health challenges, the role of the...
12.
Ansari J, Gavins F
Microcirculation
. 2021 Feb;
28(3):e12689.
PMID: 33638262
The intertwined processes of thrombosis and inflammation (termed "thrombo-inflammation") are significant drivers of cerebrovascular diseases, and as such, they represent prime targets for drug discovery programs focusing on treatment and...
13.
Ansari J, Senchenkova E, Vital S, Al-Yafeai Z, Kaur G, Sparkenbaugh E, et al.
Blood
. 2021 Jan;
137(11):1538-1549.
PMID: 33512489
Neutrophils play a crucial role in the intertwined processes of thrombosis and inflammation. An altered neutrophil phenotype may contribute to inadequate resolution, which is known to be a major pathophysiological...
14.
Vital S, Senchenkova E, Ansari J, Gavins F
Cells
. 2020 Nov;
9(11).
PMID: 33202930
Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities,...
15.
Omura S, Sato F, Park A, Fujita M, Khadka S, Nakamura Y, et al.
Front Immunol
. 2020 Aug;
11:1138.
PMID: 32733435
Virus infections have been associated with acute and chronic inflammatory central nervous system (CNS) diseases, e.g., acute flaccid myelitis (AFM) and multiple sclerosis (MS), where animal models support the pathogenic...
16.
Boltersdorf T, Ansari J, Senchenkova E, Groeper J, Pajonczyk D, Vital S, et al.
Theranostics
. 2020 Jun;
10(15):6599-6614.
PMID: 32550892
Inflammatory conditions are associated with a variety of diseases and can significantly contribute to their pathophysiology. Neutrophils are recognised as key players in driving vascular inflammation and promoting inflammation resolution....
17.
Boltersdorf T, Ansari J, Senchenkova E, Jiang L, White A, Coogan M, et al.
Dalton Trans
. 2019 Nov;
48(44):16764-16775.
PMID: 31674608
We report the design, preparation and characterisation of three small-molecule, Formyl Peptide Receptor (FPR)-targeted lanthanide complexes (Tb·14, Eu·14 and Gd·14). Long-lived, metal-based emission was observed from the terbium complex (τH2O...
18.
Becker F, Romero E, Goetzmann J, Hasselschwert D, Dray B, Vanchiere J, et al.
Am J Pathol
. 2019 Sep;
189(10):1953-1972.
PMID: 31547920
Changes in the intestinal lymphatic vascular system, such as lymphatic obstruction, are characteristic features of inflammatory bowel diseases. The lymphatic vasculature forms a conduit to enable resolution of inflammation; this...
19.
Senchenkova E, Ansari J, Becker F, Vital S, Al-Yafeai Z, Sparkenbaugh E, et al.
Circulation
. 2019 Jun;
140(4):319-335.
PMID: 31154815
Background: Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory responses is essential to restore homeostasis. Platelets play a crucial part...
20.
Ansari J, Gavins F
Am J Pathol
. 2019 Mar;
189(4):706-718.
PMID: 30904156
Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies worldwide, affecting almost 400,000 newborns globally each year. It is characterized by chronic hemolytic anemia and endothelial dysfunction,...