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Stephen J Getting

Explore the profile of Stephen J Getting including associated specialties, affiliations and a list of published articles. Areas
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Articles 39
Citations 1040
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Recent Articles
1.
Wickstead E, Elliott B, Pokorny S, Biggs C, Getting S, McArthur S
Int J Mol Sci . 2023 Nov; 24(21). PMID: 37958978
Neuroinflammation driven primarily by microglia directly contributes to neuronal death in many neurodegenerative diseases. Classical anti-inflammatory approaches aim to suppress pro-inflammatory mediator production, but exploitation of inflammatory resolution may also...
2.
Yao Z, Getting S, Locke I
Cells . 2022 Jan; 11(1). PMID: 35011694
Increased osteoclast (OC) differentiation and activity is the critical event that results in bone loss and joint destruction in common pathological bone conditions, such as osteoporosis and rheumatoid arthritis (RA)....
3.
Wickstead E, Irving M, Getting S, McArthur S
FEBS J . 2021 Apr; 289(7):1801-1822. PMID: 33811735
Alzheimer's disease and dementia are among the most significant current healthcare challenges given the rapidly growing elderly population, and the almost total lack of effective therapeutic interventions. Alzheimer's disease pathology...
4.
Wickstead E, Karim H, Manuel R, Biggs C, Getting S, McArthur S
Oxid Med Cell Longev . 2020 Jul; 2020:2139192. PMID: 32617132
Microglial inflammatory activity is thought to be a major contributor to the pathology of neurodegenerative conditions such as Alzheimer's disease (AD), and strategies to restrain their behaviour are under active...
5.
Can V, Locke I, Kaneva M, Kerrigan M, Merlino F, De Pascale C, et al.
Eur J Pharmacol . 2020 Feb; 872:172971. PMID: 32004526
Human melanocortin MC1 and MC3 receptors expressed on C-20/A4 chondrocytes exhibit chondroprotective and anti-inflammatory effects when activated by melanocortin peptides. Nearly 9 million people in the UK suffer from osteoarthritis,...
6.
Momen-Heravi F, Getting S, Moschos S
Pharmacol Ther . 2018 Aug; 192:170-187. PMID: 30081050
Extracellular vesicles (EVs) are a heterogenous population of vesicles originate from cells. EVs are found in different biofluids and carry different macromolecules, including proteins, lipids, and nucleic acids, providing a...
7.
Getting S
ScientificWorldJournal . 2018 Jun; 7:1463-1464. PMID: 29861697
No abstract available.
8.
Holloway P, Durrenberger P, Trutschl M, Cvek U, Cooper D, Orr A, et al.
Arterioscler Thromb Vasc Biol . 2015 Jun; 35(9):1936-44. PMID: 26112010
Objective: Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin (MC) receptors has previously shown to inhibit leukocyte...
9.
Kaneva M, Kerrigan M, Grieco P, Curley G, Locke I, Getting S
Biochem Pharmacol . 2014 Sep; 92(2):336-47. PMID: 25175737
Introduction: Mechanical injury can greatly influence articular cartilage, propagating inflammation, cell injury and death - risk factors for the development of osteoarthritis. Melanocortin peptides and their receptors mediate anti-inflammatory and...
10.
Gavins F, Hughes E, Buss N, Holloway P, Getting S, Buckingham J
FASEB J . 2012 Sep; 26(12):4977-89. PMID: 22964301
Unregulated inflammation underlies many diseases, including sepsis. Much interest lies in targeting anti-inflammatory mechanisms to develop new treatments. One such target is the anti-inflammatory protein annexin A1 (AnxA1) and its...