Faten A Sayed
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Explore the profile of Faten A Sayed including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
405
Followers
0
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Recent Articles
1.
Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, et al.
Neurobiol Dis
. 2023 Aug;
186:106263.
PMID: 37591465
The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed knockin mice expressing human TREM2-R47H...
2.
Sayed F, Kodama L, Fan L, Carling G, Udeochu J, Le D, et al.
Sci Transl Med
. 2021 Dec;
13(622):eabe3947.
PMID: 34851693
The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 (), a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD). Using transcriptomic analysis of...
3.
Telpoukhovskaia M, Liu K, Sayed F, Etchegaray J, Xie M, Zhan L, et al.
Sci Rep
. 2020 Aug;
10(1):13688.
PMID: 32792571
Patients with frontotemporal dementia (FTD) resulting from granulin (GRN) haploinsufficiency have reduced levels of progranulin and exhibit dysregulation in inflammatory and lysosomal networks. Microglia produce high levels of progranulin, and...
4.
Kodama L, Guzman E, Etchegaray J, Li Y, Sayed F, Zhou L, et al.
Nat Neurosci
. 2019 Dec;
23(2):167-171.
PMID: 31873194
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on...
5.
Sayed F, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(40):10172-10177.
PMID: 30232263
Alzheimer's disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. Hemizygous missense variants in...
6.
Udeochu J, Sayed F, Gan L
Neuron
. 2018 Mar;
97(5):991-993.
PMID: 29518360
Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al....
7.
Moller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, et al.
Glia
. 2016 Jun;
64(10):1788-94.
PMID: 27246804
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving...
8.
Wes P, Sayed F, Bard F, Gan L
Glia
. 2016 Apr;
64(10):1710-32.
PMID: 27100611
While histological changes in microglia have long been recognized as a pathological feature of Alzheimer's disease (AD), recent genetic association studies have also strongly implicated microglia in the etiology of...