Lihong Zhan
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Explore the profile of Lihong Zhan including associated specialties, affiliations and a list of published articles.
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19
Citations
851
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Recent Articles
1.
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park J, et al.
Nat Neurosci
. 2023 Jan;
26(3):416-429.
PMID: 36635496
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe...
2.
Drager N, Sattler S, Huang C, Teter O, Leng K, Hashemi S, et al.
Nat Neurosci
. 2022 Aug;
25(9):1149-1162.
PMID: 35953545
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences...
3.
Wang C, Fan L, Khawaja R, Liu B, Zhan L, Kodama L, et al.
Nat Commun
. 2022 Apr;
13(1):1969.
PMID: 35413950
Activation of microglia is a prominent pathological feature in tauopathies, including Alzheimer's disease. How microglia activation contributes to tau toxicity remains largely unknown. Here we show that nuclear factor kappa-light-chain-enhancer...
4.
Zhan L, Fan L, Kodama L, Sohn P, Wong M, Mousa G, et al.
Elife
. 2020 Oct;
9.
PMID: 33054973
Microglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglia rely on CSF1R signaling for survival. However, a small subset of microglia in mouse...
5.
Telpoukhovskaia M, Liu K, Sayed F, Etchegaray J, Xie M, Zhan L, et al.
Sci Rep
. 2020 Aug;
10(1):13688.
PMID: 32792571
Patients with frontotemporal dementia (FTD) resulting from granulin (GRN) haploinsufficiency have reduced levels of progranulin and exhibit dysregulation in inflammatory and lysosomal networks. Microglia produce high levels of progranulin, and...
6.
Kodama L, Guzman E, Etchegaray J, Li Y, Sayed F, Zhou L, et al.
Nat Neurosci
. 2019 Dec;
23(2):167-171.
PMID: 31873194
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on...
7.
Zhan L, Krabbe G, Du F, Jones I, Reichert M, Telpoukhovskaia M, et al.
PLoS Biol
. 2019 Feb;
17(2):e3000134.
PMID: 30735499
Microglia are resident immune cells that play critical roles in maintaining the normal physiology of the central nervous system (CNS). Remarkably, microglia have an intrinsic capacity to repopulate themselves after...
8.
Zhu L, Stein L, Kim D, Ho K, Yu G, Zhan L, et al.
Proc Natl Acad Sci U S A
. 2018 Nov;
115(48):E11388-E11396.
PMID: 30413620
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood. For unknown reasons, the choroid plexus...
9.
Sayed F, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(40):10172-10177.
PMID: 30232263
Alzheimer's disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. Hemizygous missense variants in...
10.
Kim S, Stiles S, Feichtmeier J, Ramesh N, Zhan L, Scalf M, et al.
Hum Mol Genet
. 2017 Nov;
27(2):322-337.
PMID: 29161404
Members of the conserved ubiquilin (UBQLN) family of ubiquitin (Ub) chaperones harbor an antipodal UBL (Ub-like)-UBA (Ub-associated) domain arrangement and participate in proteasome and autophagosome-mediated protein degradation. Mutations in a...