Fangbing Chen
Overview
Explore the profile of Fangbing Chen including associated specialties, affiliations and a list of published articles.
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19
Citations
211
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Recent Articles
1.
Liu K, Chen X, Chen F, Dai W, Zheng S, Ze B, et al.
Pediatr Res
. 2025 Feb;
PMID: 39962155
Background: Hypoxic ischemia (HI) is one of the common causes of neonatal brain injury, leading to neurodevelopmental disorders such as cerebral palsy, epilepsy, and cognitive deficits. In this study, we...
2.
Liu K, Kang Z, Yang M, Chen F, Xia M, Dai W, et al.
Glia
. 2024 Oct;
73(1):140-158.
PMID: 39392208
Brain vasculature formation begins with vessel invasion from the perineural vascular plexus, which expands through vessel sprouting and growth. Recent studies have indicated the existence of oligodendrocyte-vascular crosstalk during development....
3.
Cui S, Chen T, Xin D, Chen F, Zhong X, Dong C, et al.
J Neurosci
. 2024 Aug;
44(39).
PMID: 39151953
Oligodendrocyte myelination and remyelination after injury are intricately regulated by various intrinsic and extrinsic factors, including transcriptional regulators. Among these, the zinc-finger protein ZFP488 is an oligodendrocyte-enriched transcriptional regulator that...
4.
Ge W, Gou S, Zhao X, Jin Q, Zhuang Z, Zhao Y, et al.
Signal Transduct Target Ther
. 2024 Jul;
9(1):184.
PMID: 39025833
The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene therapy. However, there are concerns about the safety of this system, specifically related to the use...
5.
Shi H, Li L, Mu S, Gou S, Liu X, Chen F, et al.
BMC Biol
. 2024 May;
22(1):119.
PMID: 38769511
Background: Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency and decreasing byproducts, which proved to be challenging. Results: Here, we have...
6.
Ge W, Zhao X, Gou S, Jin Q, Chen F, Ouyang Z, et al.
Mol Ther Nucleic Acids
. 2023 Oct;
34:102035.
PMID: 37808924
Cas9 protein without sgRNAs can induce genomic damage at the cellular level . However, whether the detrimental effects occur in embryos after Cas9 treatment remains unknown. Here, using pig embryos...
7.
Zhou J, Wang J, Chen F, Zhuang Z, Chen M, Yang Y, et al.
PLoS One
. 2023 Aug;
18(8):e0289509.
PMID: 37540669
Transcription activator-like effectors (TALEs) have been widely used for genome editing, transcriptional regulation, and locus-specific DNA imaging. However, TALEs are difficult to handle in routine laboratories because of their complexity...
8.
Liang Y, Chen F, Wang K, Lai L
Front Med
. 2023 Jul;
17(3):359-387.
PMID: 37434066
Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system with an individual deaminase, enabling precise single-base substitution in DNA or RNA without generating a DNA double-strand...
9.
Jin Q, Liu X, Zhuang Z, Huang J, Gou S, Shi H, et al.
Genome Biol
. 2023 Jan;
24(1):8.
PMID: 36650523
Background: CRISPR-based toolkits have dramatically increased the ease of genome and epigenome editing. SpCas9 is the most widely used nuclease. However, the difficulty of delivering SpCas9 and inability to modulate...
10.
Chen F, Lian M, Ma B, Gou S, Luo X, Yang K, et al.
Commun Biol
. 2022 Nov;
5(1):1163.
PMID: 36323848
Cas12a can process multiple sgRNAs from a single transcript of CRISPR array, conferring advantages in multiplexed base editing when incorporated into base editor systems, which is extremely helpful given that...