Fan-Yan Wei
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Explore the profile of Fan-Yan Wei including associated specialties, affiliations and a list of published articles.
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Articles
83
Citations
1979
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Recent Articles
1.
Morishima T, Fakruddin M, Kanamori Y, Masuda T, Ogawa A, Wang Y, et al.
Sci Adv
. 2025 Feb;
11(8):eadu3011.
PMID: 39983002
Mitochondrial tRNA taurine modifications mediated by mitochondrial tRNA translation optimization 1 () is essential for the mitochondrial protein translation. deficiency was shown to induce proteostress in embryonic stem cells. A...
2.
Tejima M, Hashimoto T, Ohno O, Hoshina T, Takasaki K, Taniguchi S, et al.
ACS Med Chem Lett
. 2025 Feb;
16(2):311-316.
PMID: 39967634
Cdk5 regulatory associated protein 1-like 1 () is one of the most reliable risk genes for type 2 diabetes mellitus (T2DM). Because controls glucose-induced insulin secretion by K channel responsiveness...
3.
Matsuda S, Nakayama M, Do Y, Ishiuchi T, Yagi M, Wanrooij S, et al.
Commun Biol
. 2025 Feb;
8(1):202.
PMID: 39922921
Transcription of human mitochondrial DNA (mtDNA) begins from specific transcription promoters. In strand-asynchronous mtDNA replication, transcripts from the light-strand promoter serve as primers for leading-strand synthesis at the origin of...
4.
Arai K, Ono Y, Hirai N, Sugiura Y, Kaneko K, Matsuda S, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Nov;
1871(2):167566.
PMID: 39542224
Objective: Hepatic steatosis, the early stage of nonalcoholic fatty liver disease (NAFLD), currently lacks targeted pharmacological treatments. G protein-coupled receptors (GPCRs) in hepatocytes differentially regulate lipid metabolism depending on their...
5.
Oshima H, Ogawa A, Sano F, Akasaka H, Kawakami T, Iwama A, et al.
Nat Commun
. 2024 Nov;
15(1):9294.
PMID: 39511145
Adenosine receptors play pivotal roles in physiological processes. Adenosine A receptor (AR), the most recently identified adenosine receptor, is expressed in various tissues, exhibiting important roles in neuron, heart, and...
6.
Matsuura J, Akichika S, Wei F, Suzuki T, Yamamoto T, Watanabe Y, et al.
Commun Biol
. 2024 Oct;
7(1):1238.
PMID: 39354220
Human cytoplasmic tRNAs contain dihydrouridine modifications at positions 16 and 17 (D16/D17). The enzyme responsible for D16/D17 formation and its cellular roles remain elusive. Here, we identify DUS1L as the...
7.
Ishikawa K, Miyata D, Hattori S, Tani H, Kuriyama T, Wei F, et al.
Pharmacol Res
. 2024 Aug;
208:107374.
PMID: 39197713
Brain functions are mediated via the complex interplay between several complex factors, and hence, identifying the underlying cause of an abnormality within a certain brain region can be challenging. In...
8.
Tresky R, Miyamoto Y, Nagayoshi Y, Yabuki Y, Araki K, Takahashi Y, et al.
Nucleic Acids Res
. 2024 Jul;
52(15):9230-9246.
PMID: 38950903
In higher eukaryotes, tRNA methyltransferase 10A (TRMT10A) is responsible for N1-methylguanosine modification at position nine of various cytoplasmic tRNAs. Pathogenic mutations in TRMT10A cause intellectual disability, microcephaly, diabetes, and short...
9.
Ahmad R, Zhang L, Morita R, Tani H, Wu Y, Chujo T, et al.
Nucleic Acids Res
. 2023 Dec;
52(3):1341-1358.
PMID: 38113276
MTU1 controls intramitochondrial protein synthesis by catalyzing the 2-thiouridine modification of mitochondrial transfer RNAs (mt-tRNAs). Missense mutations in the MTU1 gene are associated with life-threatening reversible infantile hepatic failure. However,...
10.
Barayeu U, Sawa T, Nishida M, Wei F, Motohashi H, Akaike T
Br J Pharmacol
. 2023 Oct;
PMID: 37872133
For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain,...