Faika Mseeh
Overview
Explore the profile of Faika Mseeh including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
793
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0
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Recent Articles
1.
Czako B, Sun Y, McAfoos T, Cross J, Leonard P, Burke J, et al.
J Med Chem
. 2021 Oct;
64(20):15141-15169.
PMID: 34643390
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) plays a role in receptor tyrosine kinase (RTK), neurofibromin-1 (NF-1), and Kirsten rat sarcoma virus (KRAS) mutant-driven cancers, as well as in...
2.
Hamilton M, Mseeh F, McAfoos T, Leonard P, Reyna N, Harris A, et al.
J Med Chem
. 2021 Jul;
64(15):11302-11329.
PMID: 34292726
Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of l-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncology....
3.
Ma J, Goodwani S, Acton P, Buggia-Prevot V, Kesler S, Jamal I, et al.
Pain
. 2021 Apr;
162(10):2599-2612.
PMID: 33872235
Chemotherapy-induced peripheral neuropathy (CIPN) and chemotherapy-induced cognitive impairments (CICI) are common, often severe neurotoxic side effects of cancer treatment that greatly reduce quality of life of cancer patients and survivors....
4.
Sun Y, Meyers B, Czako B, Leonard P, Mseeh F, Harris A, et al.
Cancer Res
. 2020 Sep;
80(21):4840-4853.
PMID: 32928921
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2...
5.
Czako B, Marszalek J, Burke J, Mandal P, Leonard P, Cross J, et al.
J Med Chem
. 2020 Aug;
63(17):9888-9911.
PMID: 32787110
Tumor-associated macrophages (TAMs) have a significant presence in the tumor stroma across multiple human malignancies and are believed to be beneficial to tumor growth. Targeting CSF1R has been proposed as...
6.
Sun Y, Bandi M, Lofton T, Smith M, Bristow C, Carugo A, et al.
Cell Rep
. 2019 Jan;
26(2):469-482.e5.
PMID: 30625329
The plasticity of a preexisting regulatory circuit compromises the effectiveness of targeted therapies, and leveraging genetic vulnerabilities in cancer cells may overcome such adaptations. Hereditary leiomyomatosis renal cell carcinoma (HLRCC)...
7.
Brommage R, Liu J, Vogel P, Mseeh F, Thompson A, Potter D, et al.
Bone Res
. 2019 Jan;
7:2.
PMID: 30622831
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major...
8.
Powell D, Smith M, Doree D, Harris A, Greer J, DaCosta C, et al.
J Pharmacol Exp Ther
. 2017 Apr;
362(1):85-97.
PMID: 28442582
LX2761 is a potent sodium/glucose cotransporter 1 inhibitor restricted to the intestinal lumen after oral administration. Studies presented here evaluated the effect of orally administered LX2761 on glycemic control in...
9.
Goodwin N, Ding Z, Harrison B, Strobel E, Harris A, Smith M, et al.
J Med Chem
. 2017 Jan;
60(2):710-721.
PMID: 28045524
The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared as viable therapeutics to control...
10.
Petrocchi A, Leo E, Reyna N, Hamilton M, Shi X, Parker C, et al.
Bioorg Med Chem Lett
. 2016 Feb;
26(6):1503-1507.
PMID: 26898335
Structure based design of a novel class of aminopyrimidine MTH1 (MutT homolog 1) inhibitors is described. Optimization led to identification of IACS-4759 (compound 5), a sub-nanomolar inhibitor of MTH1 with...