Fadia B Dib-Hajj
Overview
Explore the profile of Fadia B Dib-Hajj including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
229
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Tyagi S, Higerd-Rusli G, Akin E, Baker C, Liu S, Dib-Hajj F, et al.
Nat Protoc
. 2024 Jun;
19(9):2771-2802.
PMID: 38831222
The construction of neuronal membranes is a dynamic process involving the biogenesis, vesicular packaging, transport, insertion and recycling of membrane proteins. Optical imaging is well suited for the study of...
2.
Tyagi S, Sarveswaran N, Higerd-Rusli G, Liu S, Dib-Hajj F, Waxman S, et al.
Front Mol Neurosci
. 2023 Apr;
16:1161028.
PMID: 37008789
Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral voltage-gated sodium (Na) channels are an attractive target for pain therapy because they initiate and propagate action potentials...
3.
Higerd-Rusli G, Tyagi S, Baker C, Liu S, Dib-Hajj F, Dib-Hajj S, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2215417120.
PMID: 36897973
Inflammation causes pain by shifting the balance of ionic currents in nociceptors toward depolarization, leading to hyperexcitability. The ensemble of ion channels within the plasma membrane is regulated by processes...
4.
Baker C, Tyagi S, Higerd-Rusli G, Liu S, Zhao P, Dib-Hajj F, et al.
Front Mol Neurosci
. 2023 Mar;
16:1130123.
PMID: 36860665
Patients treated with paclitaxel (PTX) or other antineoplastic agents can experience chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect characterized by numbness and pain. PTX interferes with microtubule-based transport, which...
5.
Higerd-Rusli G, Tyagi S, Liu S, Dib-Hajj F, Waxman S, Dib-Hajj S
J Biol Chem
. 2022 Dec;
299(1):102816.
PMID: 36539035
Neuronal function relies on the maintenance of appropriate levels of various ion channels at the cell membrane, which is accomplished by balancing secretory, degradative, and recycling pathways. Neuronal function further...
6.
Higerd-Rusli G, Alsaloum M, Tyagi S, Sarveswaran N, Estacion M, Akin E, et al.
J Neurosci
. 2022 May;
42(24):4794-4811.
PMID: 35589395
Neuronal excitability relies on coordinated action of functionally distinction channels. Voltage-gated sodium (Na) and potassium (K) channels have distinct but complementary roles in firing action potentials: Na channels provide depolarizing...
7.
Labau J, Alsaloum M, Estacion M, Tanaka B, Dib-Hajj F, Lauria G, et al.
Front Pharmacol
. 2022 Jan;
12:791740.
PMID: 34992539
Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium...
8.
Yuan J, Estacion M, Mis M, Tanaka B, Schulman B, Chen L, et al.
Brain Commun
. 2021 Sep;
3(3):fcab212.
PMID: 34557669
There is a pressing need for understanding of factors that confer resilience to pain. Gain-of-function mutations in sodium channel Nav1.7 produce hyperexcitability of dorsal root ganglion neurons underlying inherited erythromelalgia,...
9.
Akin E, Alsaloum M, Higerd G, Liu S, Zhao P, Dib-Hajj F, et al.
Brain
. 2021 Mar;
144(6):1727-1737.
PMID: 33734317
The microtubule-stabilizing chemotherapy drug paclitaxel (PTX) causes dose-limiting chemotherapy-induced peripheral neuropathy (CIPN), which is often accompanied by pain. Among the multifaceted effects of PTX is an increased expression of sodium...
10.
Chen L, Effraim P, Carrara J, Zhao P, Dib-Hajj F, Dib-Hajj S, et al.
Pain
. 2020 Jan;
161(6):1350-1360.
PMID: 31977939
Sodium channel Nav1.7, encoded by the SCN9A gene, is a well-validated target that plays a key role in controlling pain sensation. Loss-of-function mutations of Nav1.7 can cause a syndrome of...