Matthew Alsaloum
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Explore the profile of Matthew Alsaloum including associated specialties, affiliations and a list of published articles.
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12
Citations
195
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Recent Articles
1.
Tyagi S, Ghovanloo M, Alsaloum M, Effraim P, Higerd-Rusli G, Dib-Hajj F, et al.
bioRxiv
. 2025 Feb;
PMID: 39975312
Chronic pain and addiction are a significant global health challenge. Voltage-gated sodium channel Na 1.8, a pivotal driver of pain signaling, is a clinically validated target for the development of...
2.
Alsaloum M, Dib-Hajj S, Page D, Ruben P, Krainer A, Waxman S
Nat Rev Drug Discov
. 2025 Feb;
PMID: 39901031
Excitable cells - including neurons, muscle cells and cardiac myocytes - are unique in expressing high densities of voltage-gated sodium (Na) channels. This molecular adaptation enables these cells to produce...
3.
Alsaloum P, Alsaloum M, Kim T, Zheng D, Valentim C, Muste J, et al.
J Acad Ophthalmol (2017)
. 2023 Jun;
14(1):e127-e132.
PMID: 37388469
To assess the availability and content of fellowship program Web sites (FPWs) among ophthalmology subspecialties. This is a cross-sectional study. Web sites of all Association of University Professors of Ophthalmology-accredited...
4.
Alsaloum M, Alsaloum P, Rotruck J
J AAPOS
. 2023 Jun;
27(4):213-216.
PMID: 37302727
Chalazia in pediatric patients are often treated with topical antibiotics or steroids, although no strong evidence supports their use. This retrospective review of pediatric patients with chalazia did not find...
5.
Higerd-Rusli G, Alsaloum M, Tyagi S, Sarveswaran N, Estacion M, Akin E, et al.
J Neurosci
. 2022 May;
42(24):4794-4811.
PMID: 35589395
Neuronal excitability relies on coordinated action of functionally distinction channels. Voltage-gated sodium (Na) and potassium (K) channels have distinct but complementary roles in firing action potentials: Na channels provide depolarizing...
6.
Stem cell-derived sensory neurons modelling inherited erythromelalgia: normalization of excitability
Alsaloum M, Labau J, Liu S, Effraim P, Waxman S
Brain
. 2022 Jan;
146(1):359-371.
PMID: 35088838
Effective treatment of pain remains an unmet healthcare need that requires new and effective therapeutic approaches. NaV1.7 has been genetically and functionally validated as a mediator of pain. Preclinical studies...
7.
Labau J, Alsaloum M, Estacion M, Tanaka B, Dib-Hajj F, Lauria G, et al.
Front Pharmacol
. 2022 Jan;
12:791740.
PMID: 34992539
Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium...
8.
Alsaloum M, Waxman S
Trends Mol Med
. 2021 Dec;
28(2):110-122.
PMID: 34933815
There is a pressing need for more effective nonaddictive treatment options for pain. Pain signals are transmitted from the periphery into the spinal cord via dorsal root ganglion (DRG) neurons,...
9.
Alsaloum M, Labau J, Liu S, Estacion M, Zhao P, Dib-Hajj F, et al.
Sci Rep
. 2021 Dec;
11(1):24283.
PMID: 34930944
The inhibition of voltage-gated sodium (Na) channels in somatosensory neurons presents a promising novel modality for the treatment of pain. However, the precise contribution of these channels to neuronal excitability,...
10.
Alsaloum M, Labau J, Sosniak D, Zhao P, Almomani R, Gerrits M, et al.
J Neurophysiol
. 2021 Jul;
126(3):827-839.
PMID: 34320850
Small fiber neuropathy (SFN) is a common condition affecting thinly myelinated Aδ and unmyelinated C fibers, often resulting in excruciating pain and dysautonomia. SFN has been associated with several conditions,...