F J Monsma Jr
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Explore the profile of F J Monsma Jr including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Monsma Jr F, Abood L, Hoss W
Neurochem Int
. 2010 May;
17(1):9-13.
PMID: 20504596
Desensitization of the muscarinic receptor-mediated phosphoinositide (PI) turnover response in the striatum and cortex of the rat brain was examined. The rate of accumulation of inositol phosphates during carbachol-stimulated PI...
2.
Foster C, Prosser D, Agans J, Zhai Y, Smith M, Lachowicz J, et al.
J Clin Invest
. 2001 Jun;
107(12):1591-8.
PMID: 11413167
ADP plays a critical role in modulating thrombosis and hemostasis. ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Activation of P2Y1 activates phospholipase...
3.
Morse K, Behan J, Laz T, West Jr R, Greenfeder S, Anthes J, et al.
J Pharmacol Exp Ther
. 2001 Feb;
296(3):1058-66.
PMID: 11181941
Histamine exerts its numerous physiological functions through interaction with G protein-coupled receptors. Three such receptors have been defined at both the pharmacological and molecular level, while pharmacological evidence hints at...
4.
Rover S, Adam G, Cesura A, Galley G, Jenck F, Monsma Jr F, et al.
J Med Chem
. 2001 Feb;
43(7):1329-38.
PMID: 10753470
The discovery of 8-(5,8-dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1a, as a high-affinity ligand for the human ORL1 (orphanin FQ/nociceptin) receptor led to the synthesis of a series of optimized ligands. These compounds exhibit high...
5.
Zhang F, Luo L, Gustafson E, Lachowicz J, Smith M, Qiao X, et al.
J Biol Chem
. 2000 Dec;
276(11):8608-15.
PMID: 11104774
P2Y receptors are a class of G protein-coupled receptors activated primarily by ATP, UTP, and UDP. Five mammalian P2Y receptors have been cloned so far including P2Y1, P2Y2, P2Y4, P2Y6,...
6.
Shan L, Qiao X, Crona J, Behan J, Wang S, Laz T, et al.
J Biol Chem
. 2000 Sep;
275(50):39482-6.
PMID: 11010960
Neuromedin U is a neuropeptide prominently expressed in the upper gastrointestinal tract and central nervous system. Recently, GPR66/FM-3 (NmU-R1) was identified as a specific receptor for neuromedin U. A BLAST...
7.
Hedrick J, Morse K, Shan L, Qiao X, Pang L, Wang S, et al.
Mol Pharmacol
. 2000 Sep;
58(4):870-5.
PMID: 10999960
Neuromedin U (NmU) is a 25 amino acid peptide prominently expressed in the upper gastrointestinal (GI) tract and central nervous system. It is highly conserved throughout evolution and induces smooth...
8.
Boess F, Monsma Jr F, Bourson A, Zwingelstein C, Sleight A
Ann N Y Acad Sci
. 1999 Feb;
861:242-3.
PMID: 9928266
No abstract available.
9.
Boess F, Monsma Jr F, Sleight A
J Neurochem
. 1998 Nov;
71(5):2169-77.
PMID: 9798944
We have examined the ligand binding site of the serotonin 5-HT6 receptor using site-directed mutagenesis. Replacing the highly conserved Asp106 in transmembrane region III by asparagine eliminated D-[3H]-lysergic acid diethylamide...
10.
Jenck F, Moreau J, Martin J, Kilpatrick G, Reinscheid R, Monsma Jr F, et al.
Proc Natl Acad Sci U S A
. 1998 Feb;
94(26):14854-8.
PMID: 9405703
Orphanin FQ (OFQ, Nociceptin) is a recently discovered 17-amino acid neuropeptide that is structurally related to the opioid peptides but does not bind opioid receptors. OFQ has been proposed to...