F Chris H Franklin
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Explore the profile of F Chris H Franklin including associated specialties, affiliations and a list of published articles.
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41
Citations
2125
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Recent Articles
1.
Osman K, Desjardins S, Simmonds J, Burridge A, Kanyuka K, Henderson I, et al.
New Phytol
. 2024 Apr;
244(2):528-541.
PMID: 38584326
Meiotic crossovers (COs) generate genetic diversity and are crucial for viable gamete production. Plant COs are typically limited to 1-3 per chromosome pair, constraining the development of improved varieties, which...
2.
Hyde L, Osman K, Winfield M, Sanchez-Moran E, Higgins J, Henderson I, et al.
Plant Biotechnol J
. 2022 Nov;
21(2):405-418.
PMID: 36373224
Increasing crop yields through plant breeding is time consuming and laborious, with the generation of novel combinations of alleles being limited by chromosomal linkage blocks and linkage-drag. Meiotic recombination is...
3.
Higgins J, Osman K, Desjardins S, Henderson I, Edwards K, Franklin F
Biochem Soc Trans
. 2022 Jul;
50(4):1179-1186.
PMID: 35901450
Wheat is a major cereal crop that possesses a large allopolyploid genome formed through hybridisation of tetraploid and diploid progenitors. During meiosis, crossovers (COs) are constrained in number to 1-3...
4.
Lambing C, Kuo P, Kim J, Osman K, Whitbread A, Yang J, et al.
PLoS Genet
. 2022 Jul;
18(7):e1010298.
PMID: 35857772
During meiosis, DNA double-strand breaks (DSBs) occur throughout the genome, a subset of which are repaired to form reciprocal crossovers between chromosomes. Crossovers are essential to ensure balanced chromosome segregation...
5.
Desjardins S, Simmonds J, Guterman I, Kanyuka K, Burridge A, Tock A, et al.
Nat Commun
. 2022 Jun;
13(1):3644.
PMID: 35752733
FANCM suppresses crossovers in plants by unwinding recombination intermediates. In wheat, crossovers are skewed toward the chromosome ends, thus limiting generation of novel allelic combinations. Here, we observe that FANCM...
6.
Osman K, Franklin F, Sanchez-Moran E
Methods Mol Biol
. 2022 Apr;
2484:71-84.
PMID: 35461445
This chapter describes several cytogenetic procedures developed for investigating meiotic recombination in pollen mother cells (PMCs) of hexaploid wheat (Triticum aestivum) using standard fluorescence microscopy. Two basic methods are used...
7.
Martinez-Garcia M, White C, Franklin F, Sanchez-Moran E
Int J Mol Sci
. 2021 Dec;
22(23).
PMID: 34884922
DNA entanglements and supercoiling arise frequently during normal DNA metabolism. DNA topoisomerases are highly conserved enzymes that resolve the topological problems that these structures create. Topoisomerase II (TOPII) releases topological...
8.
Morgan C, White M, Franklin F, Zickler D, Kleckner N, Bomblies K
Curr Biol
. 2021 Sep;
31(21):4713-4726.e4.
PMID: 34480856
Polyploidy is a major driver of evolutionary change. Autopolyploids, which arise by within-species whole-genome duplication, carry multiple nearly identical copies of each chromosome. This presents an existential challenge to sexual...
9.
Tock A, Holland D, Jiang W, Osman K, Sanchez-Moran E, Higgins J, et al.
Genome Res
. 2021 Aug;
31(9):1614-1628.
PMID: 34426514
The hexaploid bread wheat genome comprises over 16 gigabases of sequence across 21 chromosomes. Meiotic crossovers are highly polarized along the chromosomes, with elevation in the gene-dense distal regions and...
10.
France M, Enderle J, Rohrig S, Puchta H, Franklin F, Higgins J
Proc Natl Acad Sci U S A
. 2021 Mar;
118(14).
PMID: 33782125
The synaptonemal complex is a tripartite proteinaceous ultrastructure that forms between homologous chromosomes during prophase I of meiosis in the majority of eukaryotes. It is characterized by the coordinated installation...