Unravelling Mechanisms That Govern Meiotic Crossover Formation in Wheat

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2022 Jul 28

PMID 35901450

Authors

James D Higgins

Kim Osman

Stuart D Desjardins

Ian R Henderson

Keith J Edwards

F Chris H Franklin

Affiliations

Soon will be listed here.

Abstract

Wheat is a major cereal crop that possesses a large allopolyploid genome formed through hybridisation of tetraploid and diploid progenitors. During meiosis, crossovers (COs) are constrained in number to 1-3 per chromosome pair that are predominantly located towards the chromosome ends. This reduces the probability of advantageous traits recombining onto the same chromosome, thus limiting breeding. Therefore, understanding the underlying factors controlling meiotic recombination may provide strategies to unlock the genetic potential in wheat. In this mini-review, we will discuss the factors associated with restricted CO formation in wheat, such as timing of meiotic events, chromatin organisation, pre-meiotic DNA replication and dosage of CO genes, as a means to modulate recombination.

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