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F Brad Johnson

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Articles 83
Citations 4118
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Recent Articles
1.
Estep K, Tobias J, Fernandez R, Beveridge B, Johnson F
J Mol Cell Biol . 2023 Sep; 16(3). PMID: 37771090
Although mechanisms of telomere protection are well-defined in differentiated cells, how stem cells sense and respond to telomere dysfunction, in particular telomeric double-strand breaks (DSBs), is poorly characterized. Here, we...
2.
Tichy E, Lee J, Li G, Estep K, Johnson F, Mourkioti F
NPJ Microgravity . 2023 Sep; 9(1):76. PMID: 37714858
Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to Earth and approach baseline levels during postflight...
3.
Tian Y, Wang X, Cramer Z, Rhoades J, Estep K, Ma X, et al.
Gut . 2023 Aug; 72(12):2294-2306. PMID: 37591698
Objective: Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with the majority of cases initiated by inactivation of the APC tumour suppressor. This results in the constitutive activation...
4.
Choi Y, Kim M, Rhoades J, Johnson N, Berry C, Root S, et al.
Cell Mol Gastroenterol Hepatol . 2023 Jun; 16(3):451-472. PMID: 37302654
Background & Aims: Dyskeratosis congenita (DC) is a telomere biology disorder caused primarily by mutations in the DKC1 gene. Patients with DC and related telomeropathies resulting from premature telomere dysfunction...
5.
Fernandez R, Gardner Z, Slovik K, Liberti D, Estep K, Yang W, et al.
Elife . 2022 May; 11. PMID: 35559731
Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis...
6.
Nacarelli T, Azar A, Potnis M, Johannes G, Mell J, Johnson F, et al.
Mol Biol Cell . 2022 Feb; 33(5):ar36. PMID: 35196069
Cellular senescence is a terminal cell fate characterized by growth arrest and a metabolically active state characterized by high glycolytic activity. Human fibroblasts were placed in a unique metabolic state...
7.
Pignolo R, Johnson F
J Am Geriatr Soc . 2021 Sep; 69(11):3071-3073. PMID: 34534358
No abstract available.
8.
Mei Y, Deng Z, Vladimirova O, Gulve N, Johnson F, Drosopoulos W, et al.
Sci Rep . 2021 Feb; 11(1):3509. PMID: 33568696
Telomere dysfunction causes chromosomal instability which is associated with many cancers and age-related diseases. The non-coding telomeric repeat-containing RNA (TERRA) forms a structural and regulatory component of the telomere that...
9.
Fraietta J, Lacey S, Orlando E, Pruteanu-Malinici I, Gohil M, Lundh S, et al.
Nat Med . 2021 Feb; 27(3):561. PMID: 33547459
No abstract available.
10.
Luongo T, Eller J, Lu M, Niere M, Raith F, Perry C, et al.
Nature . 2020 Sep; 588(7836):174-179. PMID: 32906142
Mitochondria require nicotinamide adenine dinucleotide (NAD) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD transporters have been identified in yeast and plants,...