F Becq
Overview
Explore the profile of F Becq including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
574
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Recent Articles
1.
Pascarel K, Colas J, Mirval S, Becq F, Vandebrouck C
Rev Mal Respir
. 2023 Feb;
40(3):230-233.
PMID: 36775781
Cystic fibrosis is a disease caused by a mutation on the CFTR gene coding for a chloride channel. The dominant mutation F508del eliminates the CFTR protein at the surface of...
2.
Bergougnoux A, Billet A, Ka C, Heller M, Degrugillier F, Vuillaume M, et al.
J Cyst Fibros
. 2022 Dec;
22(3):515-524.
PMID: 36567205
Background: The majority of variants of unknown clinical significance (VUCS) in the CFTR gene are missense variants. While change on the CFTR protein structure or function is often suspected, impact...
3.
Yefimova M, Bourmeyster N, Becq F, Burel A, Lavault M, Jouve G, et al.
Morphologie
. 2018 Dec;
103(341):4-10.
PMID: 30528305
CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function...
4.
Cendret V, Legigan T, Mingot A, Thibaudeau S, Adachi I, Forcella M, et al.
Org Biomol Chem
. 2015 Sep;
13(43):10734-44.
PMID: 26356422
The synthesis of eleven 1-deoxynojirimycin (DNJ) derivatives presenting either a monofluoro, difluoro, thiolated or unsaturated N-alkyl chain of various length is described. Exploiting the unsaturated moiety on the nitrogen, fluorine...
5.
Desire J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, et al.
Org Biomol Chem
. 2014 Oct;
12(44):8977-96.
PMID: 25277226
The glycosidase inhibitory properties of synthetic C-alkyl and N-alkyl six-membered iminosugars have been extensively studied leading to therapeutic candidates. The related seven-membered iminocyclitols have been less examined despite the report...
6.
Norez C, Vandebrouck C, Bertrand J, Noel S, Durieu E, Oumata N, et al.
Br J Pharmacol
. 2014 Jul;
171(21):4831-49.
PMID: 25065395
Background And Purpose: The most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF...
7.
Gimenez-Maitre A, Le Henaff C, Norez C, Guillaume C, Ravoninjatovo B, Laurent-Maquin D, et al.
Eur Respir J
. 2012 Mar;
39(3):780-1.
PMID: 22379154
No abstract available.
8.
Ouedraogo M, Ruiz M, Vardelle E, Carreyre H, Coustard J, Potreau D, et al.
J Ethnopharmacol
. 2010 Oct;
133(2):345-52.
PMID: 20937377
Aim Of The Study: Effects of the different fractions obtained by partition of ethanolic extract (EE) of Agelanthus dodoneifolius through column chromatography were investigated on rat blood pressure and aortic...
9.
Bertrand J, Boucherle B, Billet A, Melin-Heschel P, Dannhoffer L, Vandebrouck C, et al.
Eur Respir J
. 2010 Jan;
36(2):311-22.
PMID: 20110398
One of the major therapeutic strategy in cystic fibrosis aims at developing modulators of cystic fibrosis transmembrane conductance regulator (CFTR) channels. We recently discovered methylglyoxal alpha-aminoazaheterocycle adducts, as a new...
10.
Grand T, Demion M, Norez C, Mettey Y, Launay P, Becq F, et al.
Br J Pharmacol
. 2008 Feb;
153(8):1697-705.
PMID: 18297105
Background And Purpose: TRPM4 and TRPM5 are calcium-activated non-selective cation channels with almost identical characteristics. TRPM4 is detected in several tissues including heart, kidney, brainstem, cerebral artery and immune system...