Ewen Lescop
Overview
Explore the profile of Ewen Lescop including associated specialties, affiliations and a list of published articles.
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Articles
56
Citations
997
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Recent Articles
1.
Malard F, Sizun C, Thureau A, Carlier L, Lescop E
J Biol Chem
. 2023 May;
299(7):104830.
PMID: 37201583
Translationally Controlled Tumor Protein (TCTP) serves as a pro-survival factor in tumor cells, inhibiting the mitochondrial apoptosis pathway by enhancing the function of anti-apoptotic Bcl-2 family members Mcl-1 and Bcl-xL....
2.
Pozza A, Giraud F, Cece Q, Casiraghi M, Point E, Damian M, et al.
Nat Commun
. 2022 Apr;
13(1):1780.
PMID: 35365643
Cell membranes represent a complex and variable medium in time and space of lipids and proteins. Their physico-chemical properties are determined by lipid components which can in turn influence the...
3.
Mouhand A, Zargarian L, Belfetmi A, Catala M, Pasi M, Lescop E, et al.
Viruses
. 2022 Mar;
14(3).
PMID: 35337039
The nucleocapsid domain (NCd), located at the C-terminus of the HIV-1 Gag protein, is involved in numerous stages of the replication cycle, such as the packaging of the viral genome...
4.
Malard F, Jacquet E, Nhiri N, Sizun C, Chabrier A, Messaoudi S, et al.
ChemMedChem
. 2021 Sep;
17(1):e202100528.
PMID: 34472703
TCTP protein is a pharmacological target in cancer and TCTP inhibitors such as sertraline have been evaluated in clinical trials. The direct interaction of TCTP with the drugs sertraline and...
5.
Doyen C, Larquet E, Coureux P, Frances O, Herman F, Sable S, et al.
Mol Pharm
. 2021 Jun;
18(7):2521-2539.
PMID: 34151567
Liposomal formulations represent attractive biocompatible and tunable drug delivery systems for peptide drugs. Among the tools to analyze their physicochemical properties, nuclear magnetic resonance (NMR) spectroscopy, despite being an obligatory...
6.
Guerineau M, Bessa L, Moriau S, Lescop E, Bontems F, Mathy N, et al.
Mob DNA
. 2021 Apr;
12(1):12.
PMID: 33926516
Background: Transposons are mobile genetic elements that colonize genomes and drive their plasticity in all organisms. DNA transposon-encoded transposases bind to the ends of their cognate transposons and catalyze their...
7.
Pinet L, Wang Y, Deville C, Lescop E, Guerlesquin F, Badache A, et al.
Biophys J
. 2021 Mar;
120(10):1869-1882.
PMID: 33741354
ErbB2 (or HER2) is a receptor tyrosine kinase overexpressed in some breast cancers and associated with poor prognosis. Treatments targeting the receptor extracellular and kinase domains have greatly improved disease...
8.
Daressy F, Malard F, Seguy L, Guerineau V, Apel C, Dumontet V, et al.
ChemMedChem
. 2021 Mar;
16(11):1788-1797.
PMID: 33665938
Drimane sesquiterpenoid dialdehydes are natural compounds with antiproliferative properties. Nevertheless, their mode of action has not yet been discovered. Herein, we demonstrate that various drimanes are potent inhibitors of MCL-1...
9.
Riviere G, Oueslati S, Gayral M, Crechet J, Nhiri N, Jacquet E, et al.
ACS Omega
. 2020 May;
5(18):10466-10480.
PMID: 32426604
New Delhi metallo-β-lactamase-1 (NDM-1) has recently emerged as a global threat because of its ability to confer resistance to all common β-lactam antibiotics. Understanding the molecular basis of β-lactam hydrolysis...
10.
Arrondel C, Missoury S, Snoek R, Patat J, Menara G, Collinet B, et al.
Nat Commun
. 2019 Sep;
10(1):3967.
PMID: 31481669
N-threonyl-carbamoylation of adenosine 37 of ANN-type tRNAs (tA) is a universal modification essential for translational accuracy and efficiency. The tA pathway uses two sequentially acting enzymes, YRDC and OSGEP, the...