Eun Kyung Yoo
Overview
Explore the profile of Eun Kyung Yoo including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
146
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0
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Recent Articles
1.
Kim M, Hwang I, Pagire H, Pagire S, Choi W, Choi W, et al.
J Med Chem
. 2020 Apr;
63(8):4171-4182.
PMID: 32285676
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis. Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy homeostasis, including hepatic lipid...
2.
Min B, Oh C, Park S, Lee J, Go Y, Park B, et al.
Exp Mol Med
. 2019 Oct;
51(10):1-12.
PMID: 31570705
Dyslipidemia-induced atherosclerosis, which has a risk of high morbidity and mortality, can be alleviated by metabolic activation associated with mitochondrial function. The effect of dichloroacetate (DCA), a general pyruvate dehydrogenase...
3.
Cho H, Shin I, Cho K, Yoon H, Yoo E, Kim M, et al.
J Med Chem
. 2019 Aug;
62(18):8461-8479.
PMID: 31469962
Pyruvate dehydrogenase kinases (PDHKs) promote abnormal respiration in cancer cells. Studies with novel resorcinol amide derivatives based on VER-246608 () led to the identification of and containing five-membered heteroaromatic rings...
4.
Min B, Park S, Kang H, Kim D, Ham H, Ha C, et al.
Front Immunol
. 2019 May;
10:944.
PMID: 31134063
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion...
5.
Lee D, Pagire H, Pagire S, Bae E, Dighe M, Kim M, et al.
J Med Chem
. 2019 Feb;
62(5):2849.
PMID: 30811938
No abstract available.
6.
Kim J, Song J, Ji H, Yoo E, Lee J, Lee S, et al.
J Med Chem
. 2019 Jan;
62(4):1837-1858.
PMID: 30657313
An inverse agonist of estrogen-related receptor-γ (ERRγ), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness...
7.
Lee D, Pagire H, Pagire S, Bae E, Dighe M, Kim M, et al.
J Med Chem
. 2019 Jan;
62(2):575-588.
PMID: 30623649
Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. Structural modifications of hit anthraquinone led to the identification of a new...
8.
Park B, Jeon J, Go Y, Ham H, Kim J, Yoo E, et al.
Diabetes
. 2018 Aug;
67(10):2054-2068.
PMID: 30065033
In fasting or diabetes, gluconeogenic genes are transcriptionally activated by glucagon stimulation of the cAMP-protein kinase A (PKA)-CREB signaling pathway. Previous work showed pyruvate dehydrogenase kinase (PDK) inhibition in skeletal...
9.
Kim J, Woo S, Im C, Yoo E, Lee S, Kim H, et al.
J Med Chem
. 2016 Nov;
59(22):10209-10227.
PMID: 27805390
We evaluated the in vitro pharmacology as well as the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of chemical entities that not only were shown to be highly selective...
10.
Kim J, Chin J, Im C, Yoo E, Woo S, Hwang H, et al.
Eur J Med Chem
. 2016 May;
120:338-52.
PMID: 27236015
Estrogen-related receptor gamma (ERRγ) has recently been recognized as an attractive target for treating inflammation, cancer, and metabolic disorders. Herein, we discovered and demonstrated the in vitro pharmacology as well...