Eugene O Apostolov
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Explore the profile of Eugene O Apostolov including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
615
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Recent Articles
1.
DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity
Fahmi T, Wang X, Zhdanov D, Islam I, Apostolov E, Savenka A, et al.
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33212932
Endonuclease-mediated DNA fragmentation is both an immediate cause and a result of apoptosis and of all other types of irreversible cell death after injury. It is produced by nine enzymes...
2.
Shukla A, Bose C, Karaduta O, Apostolov E, Kaushal G, Fahmi T, et al.
PLoS One
. 2015 Sep;
10(9):e0139226.
PMID: 26414017
Cardiovascular disease is the largest cause of morbidity and mortality among patients with chronic kidney disease (CKD) and end-stage kidney disease, with nearly half of all deaths attributed to cardiovascular...
3.
Zhdanov D, Fahmi T, Wang X, Apostolov E, Sokolov N, Javadov S, et al.
DNA Cell Biol
. 2015 Apr;
34(5):316-26.
PMID: 25849439
Cells contain several apoptotic endonucleases, which appear to act simultaneously before and after cell death by destroying the host cell DNA. It is largely unknown how the endonucleases are being...
4.
Jang D, Penthala N, Apostolov E, Wang X, Crooks P, Basnakian A
DNA Cell Biol
. 2014 Nov;
34(2):92-100.
PMID: 25401220
Apoptotic endonuclease G (EndoG) is responsible for DNA fragmentation both during and after cell death. Previous studies demonstrated that genetic inactivation of EndoG is cytoprotective against various pro-apoptotic stimuli; however,...
5.
Jang D, Penthala N, Apostolov E, Wang X, Fahmi T, Crooks P, et al.
J Biomol Screen
. 2014 Oct;
20(2):202-11.
PMID: 25326282
Deoxyribonuclease I (DNase I), the most active and abundant apoptotic endonuclease in mammals, is known to mediate toxic, hypoxic, and radiation injuries to the cell. Neither inhibitors of DNase I...
6.
Apostolov E, Ok E, Burns S, Nawaz S, Savenka A, Shah S, et al.
J Atheroscler Thromb
. 2013 Sep;
20(12):878-92.
PMID: 24067603
Aim: Both oxidized LDL and carbamylated LDL are considered important for initiating atherosclerosis in patients with end-stage kidney disease through vascular endothelial cell dysfunction or injury. However their effects on...
7.
Zarjou A, Bolisetty S, Joseph R, Traylor A, Apostolov E, Arosio P, et al.
J Clin Invest
. 2013 Sep;
123(10):4423-34.
PMID: 24018561
Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: heavy chain and light chain. The ferritin heavy chain (FtH) has ferroxidase activity...
8.
Akrawinthawong K, Shaw M, Kachner J, Apostolov E, Basnakian A, Shah S, et al.
Cardiorenal Med
. 2013 Aug;
3(1):7-16.
PMID: 23946721
Background: Open heart surgery with cardiopulmonary bypass is recognized as a common cause of acute kidney injury (AKI). The conventional biomarker creatinine is not sensitive enough to detect AKI until...
9.
Singh M, Odeniyi D, Apostolov E, Savenka A, Fite T, Wangila G, et al.
Am J Physiol Renal Physiol
. 2013 Jul;
305(7):F1022-30.
PMID: 23825076
Cold storage of kidneys before transplantation is problematic because of the limited survival time of the allografts. In this study, zinc-N-acetylcysteine (ZnNAC) was shown to be a potent endonuclease inhibitor...
10.
Apostolov E, Basnakian A, Ok E, Shah S
J Ren Nutr
. 2011 Dec;
22(1):134-8.
PMID: 22200430
The high cardiovascular morbidity and mortality associated with chronic kidney disease (CKD) cannot be explained entirely by traditional risk factors. Urea spontaneously dissociates to form cyanate, which modifies proteins in ...