Eugene E Varfolomeev
Overview
Explore the profile of Eugene E Varfolomeev including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
416
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Recent Articles
1.
Austin C, Lawrence D, Peden A, Varfolomeev E, Totpal K, De Maziere A, et al.
Proc Natl Acad Sci U S A
. 2006 Jun;
103(27):10283-10288.
PMID: 16801533
Endocytosis is crucial for various aspects of cell homeostasis. Here, we show that proapoptotic death receptors (DRs) trigger selective destruction of the clathrin-dependent endocytosis machinery. DR stimulation induced rapid, caspase-mediated...
2.
Schuchmann M, Ruckert F, Garcia-Lazaro J, Karg A, Burg J, Knorr N, et al.
World J Gastroenterol
. 2006 Jan;
11(46):7248-53.
PMID: 16437623
Aim: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). Methods: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the...
3.
Kang T, Ben-Moshe T, Varfolomeev E, Pewzner-Jung Y, Yogev N, Jurewicz A, et al.
J Immunol
. 2004 Aug;
173(5):2976-84.
PMID: 15322156
Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by receptors of the TNF/nerve growth factor family, is lethal to mice in utero. To explore...
4.
Varfolomeev E, Ashkenazi A
Cell
. 2004 Feb;
116(4):491-7.
PMID: 14980217
TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and...
5.
Schuchmann M, Varfolomeev E, Hermann F, Rueckert F, Strand D, Koehler H, et al.
Hepatology
. 2002 Dec;
37(1):129-35.
PMID: 12500197
Derangement of the apoptotic program is considered an important cause of liver disease. It became clear that receptor-mediated apoptosis is of specific interest in this context, and CD95 and CD120a,...
6.
Wallach D, Arumugam T, Boldin M, Cantarella G, Ganesh K, Goltsev Y, et al.
Arthritis Res
. 2002 Jul;
4 Suppl 3:S189-96.
PMID: 12110139
Signals emanating from receptors of the tumor necrosis factor/nerve growth factor (TNF/NGF) family control practically all aspects of immune defense and, as such, constitute potential targets for therapeutic intervention through...