David Wallach
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Explore the profile of David Wallach including associated specialties, affiliations and a list of published articles.
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55
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6084
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Recent Articles
1.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
2.
Yoon S, Bogdanov K, Wallach D
Cell Death Differ
. 2022 Jan;
29(2):306-322.
PMID: 34999730
Phosphorylation of the pseudokinase mixed lineage kinase domain-like protein (MLKL) by the protein kinase RIPK3 targets MLKL to the cell membrane, where it triggers necroptotic cell death. We report that...
3.
Boix-Amoros A, Piras E, Bu K, Wallach D, Stapylton M, Fernandez-Sesma A, et al.
mSystems
. 2021 Oct;
6(5):e0067421.
PMID: 34609165
The global emergence of novel pathogenic viruses presents an important challenge for research, as high biosafety levels are required to process samples. While inactivation of infectious agents facilitates the use...
4.
Wallach D, Kang T
Immunity
. 2018 Jul;
49(1):19-32.
PMID: 30021143
Cell-culture studies are our main source of knowledge of the various forms of programmed cell death. Yet genetic perturbations of death-protein function in animal models are almost the only source...
5.
Kang T, Jeong J, Yang S, Kovalenko A, Wallach D
Cell Death Differ
. 2018 Apr;
25(6):1107-1117.
PMID: 29666472
Deletion of the Casp8 gene in epithelial tissues of mice results in severe inflammatory pathologies. Its ubiquitous deletion, or its specific deletion in endothelial cells, results in intrauterine death associated...
6.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Galluzzi L, Vitale I, Aaronson S, Abrams J, Adam D, Agostinis P, et al.
Cell Death Differ
. 2018 Jan;
25(3):486-541.
PMID: 29362479
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the...
7.
Gyrd-Hansen M, Farkas T, Fehrenbacher N, Bastholm L, Hoyer-Hansen M, Elling F, et al.
Mol Cell Biol
. 2017 Dec;
38(2).
PMID: 29288151
No abstract available.
8.
Boege Y, Malehmir M, Healy M, Bettermann K, Lorentzen A, Vucur M, et al.
Cancer Cell
. 2017 Sep;
32(3):342-359.e10.
PMID: 28898696
Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and...
9.
Wallach D
Cold Spring Harb Perspect Biol
. 2017 Aug;
10(10).
PMID: 28847899
The tumor necrosis factor (TNF) cytokine family and the TNF/nerve growth factor (NGF) family of their cognate receptors together control numerous immune functions, as well as tissue-homeostatic and embryonic-development processes....
10.
Yoon S, Kovalenko A, Bogdanov K, Wallach D
Immunity
. 2017 Jul;
47(1):51-65.e7.
PMID: 28666573
Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell death in which rupture of cellular...