Ester Falconer
Overview
Explore the profile of Ester Falconer including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
994
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Recent Articles
1.
Westendorf K, Zentelis S, Wang L, Foster D, Vaillancourt P, Wiggin M, et al.
Cell Rep
. 2022 May;
39(7):110812.
PMID: 35568025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of concern (VOCs)...
2.
Hsieh C, Werner A, Leist S, Stevens L, Falconer E, Goldsmith J, et al.
Cell Rep
. 2021 Oct;
37(5):109929.
PMID: 34710354
Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein...
3.
Westendorf K, Zentelis S, Wang L, Foster D, Vaillancourt P, Wiggin M, et al.
bioRxiv
. 2021 May;
PMID: 33972947
In Brief: LY-CoV1404 is a potent SARS-CoV-2-binding antibody that neutralizes all known variants of concern and whose epitope is rarely mutated. Highlights: LY-CoV1404 potently neutralizes SARS-CoV-2 authentic virus and known...
4.
Jones B, Brown-Augsburger P, Corbett K, Westendorf K, Davies J, Cujec T, et al.
Sci Transl Med
. 2021 Apr;
13(593).
PMID: 33820835
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics that may...
5.
Hills M, Falconer E, ONeill K, Sanders A, Howe K, Guryev V, et al.
Int J Mol Sci
. 2021 Apr;
22(7).
PMID: 33807210
Accurate reference genome sequences provide the foundation for modern molecular biology and genomics as the interpretation of sequence data to study evolution, gene expression, and epigenetics depends heavily on the...
6.
Jones B, Brown-Augsburger P, Corbett K, Westendorf K, Davies J, Cujec T, et al.
bioRxiv
. 2020 Oct;
PMID: 33024963
One Sentence Summary: LY-CoV555, an anti-spike antibody derived from a convalescent COVID-19 patient, potently neutralizes SARS-CoV-2 and protects the upper and lower airways of non-human primates against SARS-CoV-2 infection.
7.
Sanders A, Falconer E, Hills M, Spierings D, Lansdorp P
Nat Protoc
. 2017 May;
12(6):1151-1176.
PMID: 28492527
The ability to distinguish between genome sequences of homologous chromosomes in single cells is important for studies of copy-neutral genomic rearrangements (such as inversions and translocations), building chromosome-length haplotypes, refining...
8.
Porubsky D, Sanders A, van Wietmarschen N, Falconer E, Hills M, Spierings D, et al.
Genome Res
. 2016 Sep;
26(11):1565-1574.
PMID: 27646535
Haplotypes are fundamental to fully characterize the diploid genome of an individual, yet methods to directly chart the unique genetic makeup of each parental chromosome are lacking. Here we introduce...
9.
Sanders A, Hills M, Porubsky D, Guryev V, Falconer E, Lansdorp P
Genome Res
. 2016 Jul;
26(11):1575-1587.
PMID: 27472961
Identifying genomic features that differ between individuals and cells can help uncover the functional variants that drive phenotypes and disease susceptibilities. For this, single-cell studies are paramount, as it becomes...
10.
van den Bos H, Spierings D, Taudt A, Bakker B, Porubsky D, Falconer E, et al.
Genome Biol
. 2016 Jul;
17(1):143.
PMID: 27363435
No abstract available.