Erwan Beauchamp
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Explore the profile of Erwan Beauchamp including associated specialties, affiliations and a list of published articles.
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24
Citations
383
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Recent Articles
1.
Guajardo-Contreras G, Abdalla A, Chen A, Niu M, Beauchamp E, Berthiaume L, et al.
J Cell Sci
. 2024 Oct;
137(22).
PMID: 39439384
Macrophages represent an important viral reservoir in HIV-1-infected individuals. Different from T cells, HIV-1 assembly in macrophages occurs at intracellular compartments termed virus-containing compartments (VCCs). Our previous research in HeLa...
2.
Gamma J, Liu Q, Beauchamp E, Iyer A, Yap M, Zak Z, et al.
Mol Cancer Ther
. 2024 Oct;
24(1):69-80.
PMID: 39382188
Acute myeloid leukemia (AML) is a hematologic malignancy with limited treatment options and a high likelihood of recurrence after chemotherapy. We studied N-myristoylation, the myristate modification of proteins linked to...
3.
Sangha R, Jamal R, Spratlin J, Kuruvilla J, Sehn L, Beauchamp E, et al.
Invest New Drugs
. 2024 Jun;
42(4):386-393.
PMID: 38837078
Myristoylation, the N-terminal addition of the fatty acid myristate to proteins, regulates membrane-bound signal transduction pathways important in cancer cell biology. This modification is catalyzed by two N-myristoyltransferases, NMT1 and...
4.
Beauchamp E, Gamma J, Cromwell C, Moussa E, Pain R, Kostiuk M, et al.
J Transl Med
. 2024 May;
22(1):431.
PMID: 38715059
Background: In humans, two ubiquitously expressed N-myristoyltransferases, NMT1 and NMT2, catalyze myristate transfer to proteins to facilitate membrane targeting and signaling. We investigated the expression of NMTs in numerous cancers...
5.
Sangha R, Davies N, Namdar A, Chu M, Spratlin J, Beauchamp E, et al.
Curr Oncol
. 2022 Mar;
29(3):1939-1946.
PMID: 35323358
Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) have limited treatment options, particularly if they are transplantation or chimeric antigen receptor (CAR) T-cell ineligible, and novel therapeutics are...
6.
Mackey J, Lai J, Chauhan U, Beauchamp E, Dong W, Glubrecht D, et al.
Breast Cancer Res Treat
. 2021 Jan;
186(1):79-87.
PMID: 33398478
Purpose: N-myristoyltransferases 1 and 2 (NMT1 and NMT2) catalyze the addition of 14-carbon fatty acids to the N-terminus of proteins. Myristoylation regulates numerous membrane-bound signal transduction pathways important in cancer...
7.
Beauchamp E, Yap M, Iyer A, Perinpanayagam M, Gamma J, Vincent K, et al.
Nat Commun
. 2020 Oct;
11(1):5348.
PMID: 33093447
Myristoylation, the N-terminal modification of proteins with the fatty acid myristate, is critical for membrane targeting and cell signaling. Because cancer cells often have increased N-myristoyltransferase (NMT) expression, NMTs were...
8.
Lemarie F, Beauchamp E, Drouin G, Legrand P, Rioux V
Prostaglandins Leukot Essent Fatty Acids
. 2018 Aug;
135:121-127.
PMID: 30103923
Caprylic acid (octanoic acid, C8:0) belongs to the class of medium-chain saturated fatty acids (MCFAs). Dairy products and specific oils such as coconut oil are natural sources of dietary caprylic...
9.
Zheng W, Yang J, Beauchamp E, Cai R, Hussein S, Hofmann L, et al.
J Biol Chem
. 2016 Oct;
291(49):25678-25691.
PMID: 27754867
Transient receptor potential polycystin-3 (TRPP3) is a cation channel activated by calcium and proton and is involved in hedgehog signaling, intestinal development, and sour tasting. How TRPP3 channel function is...
10.
McFie P, Izzard S, Vu H, Jin Y, Beauchamp E, Berthiaume L, et al.
Biochim Biophys Acta
. 2016 Jul;
1861(9 Pt A):1192-1204.
PMID: 27373844
Acyl CoA:2-monoacylglycerol acyltransferase (MGAT)-2 has an important role in dietary fat absorption in the intestine. MGAT2 resides in the endoplasmic reticulum and catalyzes the synthesis of diacylglycerol which is then...