Erin Harleton
Overview
Explore the profile of Erin Harleton including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
146
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Recent Articles
1.
Qiu X, Chauveau S, Anyukhovsky E, Rahim T, Jiang Y, Harleton E, et al.
Circ Arrhythm Electrophysiol
. 2016 Apr;
9(4):e003655.
PMID: 27071826
Background: Drugs are screened for delayed rectifier potassium current (IKr) blockade to predict long QT syndrome prolongation and arrhythmogenesis. However, single-cell studies have shown that chronic (hours) exposure to some...
2.
Harleton E, Besana A, Chandra P, Danilo Jr P, Rosen T, Rosen M, et al.
Am J Physiol Heart Circ Physiol
. 2014 Dec;
308(2):H126-34.
PMID: 25437921
Atrial fibrillation (AF) is a common arrhythmia with significant morbidities and only partially adequate therapeutic options. AF is associated with atrial remodeling processes, including changes in the expression and function...
3.
Harleton E, Besana A, Comas G, Danilo Jr P, Rosen T, Argenziano M, et al.
J Biol Chem
. 2012 Dec;
288(4):2829-38.
PMID: 23229553
Peri-operative atrial fibrillation (peri-op AF) is a common complication following thoracic surgery. This arrhythmia is thought to be triggered by an inflammatory response and can be reproduced in various animal...
4.
Rybin V, Guo J, Harleton E, Zhang F, Steinberg S
J Biol Chem
. 2012 May;
287(27):22609-15.
PMID: 22582392
The canonical pathway for protein kinase D1 (PKD1) activation by growth factor receptors involves diacylglycerol binding to the C1 domain and protein kinase C-dependent phosphorylation at the activation loop. PKD1...
5.
Rybin V, Guo J, Harleton E, Feinmark S, Steinberg S
Biochemistry
. 2009 Apr;
48(21):4642-51.
PMID: 19366211
Protein kinase C-delta (PKCdelta) is a Ser/Thr kinase that regulates a wide range of cellular responses. This study identifies novel in vitro PKCdelta autophosphorylation sites at Thr(141) adjacent to the...
6.
Sumandea M, Rybin V, Hinken A, Wang C, Kobayashi T, Harleton E, et al.
J Biol Chem
. 2008 Jun;
283(33):22680-9.
PMID: 18550549
Our study identifies tyrosine phosphorylation as a novel protein kinase Cdelta (PKCdelta) activation mechanism that modifies PKCdelta-dependent phosphorylation of cardiac troponin I (cTnI), a myofilament regulatory protein. PKCdelta phosphorylates cTnI...
7.
Bamford N, Zhang H, Joyce J, Scarlis C, Hanan W, Wu N, et al.
Neuron
. 2008 Apr;
58(1):89-103.
PMID: 18400166
Addiction-associated behaviors such as drug craving and relapse are hypothesized to result from synaptic changes that persist long after withdrawal and are renormalized by drug reinstatement, although such chronic synaptic...
8.
Sridar C, Harleton E, Hollenberg P
Biochem Biophys Res Commun
. 2005 Sep;
338(1):386-93.
PMID: 16157292
We have previously observed that the quadruple (S407T-N417D-A419T-K473M) and triple (S407T-N17D-A419T) mutants of the chimeric construct of P450 2B1/2B2 do not undergo mechanism-based inactivation by 17alpha-ethynylestradiol (17EE) and tert-butyl 1-methyl-2-propynyl...
9.
Harleton E, Webster M, Bumpus N, Kent U, Rae J, Hollenberg P
J Pharmacol Exp Ther
. 2004 May;
310(3):1011-9.
PMID: 15121764
The anticancer drug N,N,"N"-triethylenethiophosphoramide (tTEPA) inactivated CYP2B6 and CYP2B1 in the reconstituted system in a time-, concentration-, and NADPH-dependent manner indicative of mechanism-based inactivation. The KI value for the inactivation...