Erik Upeslacis
Overview
Explore the profile of Erik Upeslacis including associated specialties, affiliations and a list of published articles.
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5
Citations
99
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Recent Articles
1.
Arensman M, Yang X, Zhong W, Bisulco S, Upeslacis E, Rosfjord E, et al.
Oncoimmunology
. 2020 Sep;
9(1):1800162.
PMID: 32923161
Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it...
2.
Mathur D, Root A, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, et al.
Clin Cancer Res
. 2020 Jan;
26(9):2188-2202.
PMID: 31996389
Purpose: Gastrointestinal cancers remain areas of high unmet need despite advances in targeted and immunotherapies. Here, we demonstrate potent, tumor-selective efficacy with PF-07062119, a T-cell engaging CD3 bispecific targeting tumors...
3.
Damelin M, Bankovich A, Park A, Aguilar J, Anderson W, Santaguida M, et al.
Clin Cancer Res
. 2015 May;
21(18):4165-73.
PMID: 26015513
Purpose: Triple-negative breast cancer (TNBC) and ovarian cancer each comprise heterogeneous tumors, for which current therapies have little clinical benefit. Novel therapies that target and eradicate tumor-initiating cells (TIC) are...
4.
Unsal-Kacmaz K, Ragunathan S, Rosfjord E, Dann S, Upeslacis E, Grillo M, et al.
Mol Oncol
. 2012 Jan;
6(3):284-98.
PMID: 22217540
PKN3 is an AGC-family protein kinase implicated in growth of metastatic prostate cancer cells with phosphoinositide 3-kinase pathway deregulation. The molecular mechanism, however, by which PKN3 contributes to malignant growth...
5.
Zhang N, Ayral-Kaloustian S, Niu C, Nguyen T, Upeslacis E, Mansour T, et al.
Bioorg Med Chem Lett
. 2010 Jul;
20(13):3903-5.
PMID: 20627558
A series of 2-(4-aminophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols have been developed as antitumor agents that showed high selectivity against aneuploid cell lines (vs diploid cell lines). Structure-activity relationship studies showed that a hydroxymethyl group...