Erik Segerdell
Overview
Explore the profile of Erik Segerdell including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
1681
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0
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Recent Articles
1.
Matentzoglu N, Bello S, Stefancsik R, Alghamdi S, Anagnostopoulos A, Balhoff J, et al.
Genetics
. 2025 Mar;
PMID: 40048704
Phenotypic data are critical for understanding biological mechanisms and consequences of genomic variation, and are pivotal for clinical use cases such as disease diagnostics and treatment development. For over a...
2.
Matentzoglu N, Bello S, Stefancsik R, Alghamdi S, Anagnostopoulos A, Balhoff J, et al.
bioRxiv
. 2024 Sep;
PMID: 39345458
Phenotypic data are critical for understanding biological mechanisms and consequences of genomic variation, and are pivotal for clinical use cases such as disease diagnostics and treatment development. For over a...
3.
Fisher M, James-Zorn C, Ponferrada V, Bell A, Sundararaj N, Segerdell E, et al.
Genetics
. 2023 Feb;
224(1).
PMID: 36755307
Xenbase (https://www.xenbase.org/), the Xenopus model organism knowledgebase, is a web-accessible resource that integrates the diverse genomic and biological data from research on the laboratory frogs Xenopus laevis and Xenopus tropicalis....
4.
Fisher M, Segerdell E, Matentzoglu N, Nenni M, Fortriede J, Chu S, et al.
BMC Bioinformatics
. 2022 Mar;
23(1):99.
PMID: 35317743
Background: Ontologies of precisely defined, controlled vocabularies are essential to curate the results of biological experiments such that the data are machine searchable, can be computationally analyzed, and are interoperable...
5.
Shefchek K, Harris N, Gargano M, Matentzoglu N, Unni D, Brush M, et al.
Nucleic Acids Res
. 2019 Nov;
48(D1):D704-D715.
PMID: 31701156
In biology and biomedicine, relating phenotypic outcomes with genetic variation and environmental factors remains a challenge: patient phenotypes may not match known diseases, candidate variants may be in genes that...
6.
Lie S, Rochet E, Segerdell E, Ma Y, Ashander L, Shadforth A, et al.
Front Immunol
. 2019 May;
10:708.
PMID: 31118929
Ocular toxoplasmosis is the commonest clinical manifestation of infection with obligate intracellular parasite, . Active ocular toxoplasmosis is characterized by replication of tachyzoites in the retina, with reactive inflammation. The...
7.
Nenni M, Fisher M, James-Zorn C, Pells T, Ponferrada V, Chu S, et al.
Front Physiol
. 2019 Mar;
10:154.
PMID: 30863320
At a fundamental level most genes, signaling pathways, biological functions and organ systems are highly conserved between man and all vertebrate species. Leveraging this conservation, researchers are increasingly using the...
8.
Zhang H, Savage S, Schultz A, Bottomly D, White L, Segerdell E, et al.
Nat Commun
. 2019 Jan;
10(1):244.
PMID: 30651561
FLT3 mutations are prevalent in AML patients and confer poor prognosis. Crenolanib, a potent type I pan-FLT3 inhibitor, is effective against both internal tandem duplications and resistance-conferring tyrosine kinase domain...
9.
Tyner J, Tognon C, Bottomly D, Wilmot B, Kurtz S, Savage S, et al.
Nature
. 2018 Oct;
562(7728):526-531.
PMID: 30333627
The implementation of targeted therapies for acute myeloid leukaemia (AML) has been challenging because of the complex mutational patterns within and across patients as well as a dearth of pharmacologic...
10.
James-Zorn C, Ponferrada V, Fisher M, Burns K, Fortriede J, Segerdell E, et al.
Methods Mol Biol
. 2018 May;
1757:251-305.
PMID: 29761462
Xenbase is the Xenopus model organism database ( www.xenbase.org ), a web-accessible resource that integrates the diverse genomic and biological data for Xenopus research. It hosts a variety of content...